Treatment of 5/6 nephrectomy rats with sulodexide: a novel therapy for chronic renal failure.

Acta Pharmacologica Sinica
Ping LiXiang-mei Chen

Abstract

Sulodexide, a glycosaminoglycan, could reduce albuminuria in diabetic patients. The aim of this study was to determine whether sulodexide could be used to treat chronic kidney failure in rats. Sixty Wistar rats undergone 5/6 nephrectomy, then were randomly divided into 4 groups: the model group, sulodexide group (sulodexide 5 mg/kg per day, im), irbesartan group irbesartan (20 mg/kg per day, ig) and sulodexide plus irbesartan group. Another 12 rats were enrolled into the sham operation group. After the treatments for 4, 8 and 12 weeks, urinary protein and serum creatinine levels were measured. After 12 weeks, serum cholesterin and triglycerides levels were measured, and the degrees of glomerular sclerosis and renal tubulointerstitial fibrosis were scored. The expression of aminopeptidase P (JG-12) in the renal tissue was examined using immunohistochemical staining. The renal expressions of endothelial nitric oxide synthase (eNOS) and tissue type plasminogen activator (tPA) were detected with RT-PCR and Western blot. Proteinuria was markedly attenuated in the sulodexide-treated groups. After 4 and 8 weeks only the sulodexide-treated groups showed significant reduction in serum creatinine; while after 12 weeks all the three treat...Continue Reading

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Citations

Jan 7, 2014·Drug Design, Development and Therapy·Sergio Coccheri, Ferdinando Mannello
Jul 18, 2015·British Journal of Clinical Pharmacology·Rik H G Olde EngberinkLiffert Vogt
Sep 21, 2017·International Journal of Molecular Sciences·Ehécatl Miguel Ángel García TrejoHoracio Osorio Alonso
Jul 22, 2015·Asian Pacific Journal of Tropical Medicine·Zhi-Kui WangHai-Bo Yu
Sep 26, 2015·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Diana-Silvia ZilişteanuM Voiculescu
Oct 30, 2018·Frontiers in Medicine·Ana Carolina de BragançaRildo Aparecido Volpini
Apr 20, 2021·Frontiers in Medicine·Michele Santiago Dos SantosAna Carolina de Bragança

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