PMID: 6167845Jan 1, 1981Paper

Treatment of a primary intracranial germ cell tumor with systemic chemotherapy

Medical and Pediatric Oncology
J J KirshnerR L Comis

Abstract

Primary germ cell neoplasms of the central nervous system (CNS) are rare tumors which generally respond to radiotherapy. Experience is limited in managing the refractory patient. We report a patient whose suprasellar dysgerminoma responded completely to 5,000 rad. Seven years later, disease recurrence was refractory to an additional 4,000 rad. Theorizing that the "blood-brain barrier" was no longer intact after extensive radiotherapy and tumor involvement of the ventricular system, the patient was treated with systemic bleomycin, cisplatin, and vinblastine. Pharmacokinetic studies revealed that the bleomycin and cisplatin entered the cerebrospinal fluid. Serial CT scans and CSF levels of beta-HCG confirmed the clinical impression of a partial remission. Subsequent tumor progression was refractory to therapy with intraventricular bleomycin. It is concluded that systemic chemotherapy may be beneficial in certain cases of CNS germ cell neoplasms.

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Citations

Aug 1, 1985·Journal of Neurosurgery·M T JenningsF Hochberg
Feb 1, 1987·Journal of Neurosurgery·S L GrazianoR L Comis
Jan 1, 1988·Journal of Neuro-oncology·R W WalkerJ B Posner
Dec 1, 1983·Cancer Treatment Reviews·D M Green
Oct 1, 1983·The American Journal of Medicine·C S KasperJ D Wilson
Feb 1, 1991·Surgical Neurology·S MatsuokaA Tanimura
Jul 27, 2000·British Journal of Neurosurgery·O GanslandtG G Grabenbauer
Jan 15, 1994·International Journal of Radiation Oncology, Biology, Physics·D J StewartG P Raaphorst

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