PMID: 9527154Apr 4, 1998Paper

Treatment of accidental high dose intraventricular mezlocillin application by cerebrospinal fluid exchange

Journal of Neurology, Neurosurgery, and Psychiatry
R A KristofJ Schramm

Abstract

An accidental high dose of intraventricular mezlocillin was given during antibiotic treatment for pneumonia in a patient admitted because of severe traumatic brain injury and occlusive hydrocephalus. Because of serial epileptic seizures not responsive to antiepileptic drug treatment, CSF exchange was performed. The CSF was drained through a ventricular catheter, while mock CSF was infused into the lumbar subarachnoid space. The patient soon recovered to her clinical status previous to intraventricular mezlocillin application. Side effects of CSF exchange were not seen. Under continued antiepileptic medication no more seizures occurred. It is concluded that high doses of intraventricular mezlocillin have proconvulsive effects. In this patient CSF exchange was a suitable means of preventing putatively permanent impairment of brain function caused by serial epileptic seizures due to intraventricular mezlocillin application.

Citations

Apr 24, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A H GaurJ L Shenep
Jan 30, 2008·Anesthesia and Analgesia·Stephen Howell, Richard P Driver
Apr 5, 2014·Seminars in Dialysis·Georges OuelletBrian Scott Decker
Jul 5, 2011·American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses·Paul McConnell, Catriona Macneil
Jul 30, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Samuel DeshayesRenaud Verdon
Aug 16, 2008·Experimental Biology and Medicine·Ankica V JelenkovicBogdan S Boskovic

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