Abstract
Actinic keratosis (AK) represents a risk of progression to squamous cell carcinoma. Ingenol mebutate gel is a novel therapeutic option for field-directed treatment. To evaluate the safety, tolerability and patients' perspectives, related to the therapeutic success of managing AKs on the face and scalp with ingenol mebutate gel in Brazilian individuals. This was an observational, retrospective and descriptive study of 68 areas of actinic keratosis on the face and scalp treated with Ingenol mebutate gel involving a total of 37 patients. The drug was applied for three consecutive days on an area of of 25 cm2 and documentation was performed on baseline and days 4, 8, 15, 60 and 180. On day 4, the composite local skin reaction score was calculated. At the end, a questionnaire was applied to evaluate patients' perspectives about the treatment. Adherence was 100%, no serious adverse events were recorded and the mean composite local skin reaction score (standard deviation) was 8.61±4.22. The treatment was considered optimum by 75.68% of the patients. Calculation of composite local skin reaction score performed only on the fourth day. Treatment with ingenol mebutate gel was considered safe and tolerable in Brazilian subjects. Patients h...Continue Reading
References
Apr 9, 1988·Lancet·R MarksT S Selwood
Oct 1, 1994·The British Journal of Dermatology·C A Frost, A C Green
Mar 7, 2002·Critical Reviews in Oncology/hematology·Janine G EinspahrDavid S Alberts
Apr 17, 2004·Cancer Research·Steven M OgbournePeter G Parsons
Dec 11, 2007·The British Journal of Dermatology·M VatveG Gupta
Feb 13, 2008·Cancer Immunology, Immunotherapy : CII·Peter HampsonG Ed Rainger
Jun 3, 2009·Cadernos de saúde pública·Priscila IshiokaSérgio Yamada
Nov 8, 2011·Journal of the American Academy of Dermatology·Robert H RosenStephen K Tyring
Mar 16, 2012·The New England Journal of Medicine·Mark LebwohlBrian Berman
Sep 8, 2012·Clinical, Cosmetic and Investigational Dermatology·Brian Berman
Apr 5, 2013·JAMA Dermatology·Mark LebwohlStephen K Tyring
Aug 21, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Femida H Gwadry-SridharMaja Grubisic
Aug 15, 2014·European Journal of Dermatology : EJD·Kyriaki TzoganiFrancesco Pignatti
Mar 3, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·L P SamoranoJ A Sanches
Apr 14, 2015·International Journal of Dermatology·Eggert StockflethMark Lebwohl
Aug 25, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·G PellacaniS Puig
Sep 16, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·R N WernerUNKNOWN European Dermatology Forum
Oct 9, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Stephan A Braun, Peter A Gerber
Oct 17, 2015·The British Journal of Dermatology·C GarbeJ T Lear
Nov 3, 2015·Expert Opinion on Drug Safety·Brian Berman
Apr 5, 2016·The Journal of Dermatological Treatment·Francesco RicciKetty Peris
Apr 12, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·K PerisG Pellacani
Dec 14, 2016·The New England Journal of Medicine·Rachel E ShermanRobert M Califf
Jan 18, 2017·The British Journal of Dermatology·D de BerkerB R Hughes