Treatment of acute exacerbations of interstitial lung disease

Expert Review of Respiratory Medicine
Natalya AzadehJay H Ryu

Abstract

Interstitial lung diseases (ILD) include a broad range of diffuse parenchymal lung disorders of known and unknown etiologies. Patients with ILD can experience acute exacerbations (AE) which are associated with extremely high morbidity and mortality. Little is known about the etiology of AEs, and whether inciting triggers (such as infection) result in an aberrant inflammatory response in a predisposed host. Areas covered: The majority of data regarding AE-ILD comes from the idiopathic pulmonary fibrosis (IPF) population and is extrapolated to other forms of ILD. For the purposes of this review we have summarized the current literature regarding AE of IPF, and when available have included data from AE of other ILDs. Expert commentary: Therapeutic options for AE are limited without definitive treatments available, and the prognosis is often poor. Treatment is mainly based on correcting hypoxemia, looking for reversible etiologies of respiratory decline, and palliation of symptoms. Overall little is known about the pathogenesis of ILDs and AE-ILD, more research is needed in hopes of identifying better treatment options.

References

Apr 8, 1999·American Journal of Respiratory and Critical Care Medicine·J P StewartA A Woodcock
Sep 5, 2002·Journal of Clinical Apheresis·Kenji TsushimaYutaka Kan-Nou
Sep 17, 2002·American Journal of Respiratory and Critical Care Medicine·Ghulam SaydainSteve G Peters
Jun 7, 2003·Journal of Clinical Microbiology·Yi-Wei TangArlene A Stecenko
Nov 11, 2005·Critical Care : the Official Journal of the Critical Care Forum·Hidehiko KushiKatsuhisa Tanjoh
Jun 23, 2007·American Journal of Respiratory and Critical Care Medicine·Harold R CollardUNKNOWN Idiopathic Pulmonary Fibrosis Clinical Research Network Investigators
Feb 8, 2008·The European Respiratory Journal·C E DanielsJ H Ryu
Jun 24, 2009·Respiration; International Review of Thoracic Diseases·Corrado MollicaClaudio Terzano
Jun 16, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tristan J HuieStephen K Frankel
Jul 3, 2010·The European Respiratory Journal·J W SongD S Kim
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Aug 24, 2011·Respiration; International Review of Thoracic Diseases·Virginie Simon-BlancalJean-Marc Naccache
Oct 14, 2011·The New England Journal of Medicine·Luca RicheldiRoland M du Bois
Dec 3, 2011·The European Respiratory Journal·Eoin P JudgeJim J Egan
Jan 14, 2012·The European Respiratory Journal·Marco MuraPaola Rogliani
Apr 17, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yoshimasa MizunoHirofumi Takemura
Oct 1, 2009·Journal of Bronchology & Interventional Pulmonology·Masashi BandoYukihiko Sugiyama
Jun 20, 2013·International Journal of Medical Sciences·Juanjuan DingKeqing Feng
Jul 16, 2013·Respiratory Research·Harold R CollardUNKNOWN IPFnet investigators
Nov 2, 2013·The European Respiratory Journal·Kerri A JohannsonHarold R Collard
May 20, 2014·Respiratory Medicine·Shinichiro OhshimoUlrich Costabel
May 20, 2014·Pulmonary Pharmacology & Therapeutics·Kenji TsushimaKoichiro Tatsumi
Sep 2, 2014·Respiratory Research·Keishi OdaHiroshi Mukae
Dec 10, 2015·American Journal of Respiratory and Critical Care Medicine·John P HutchinsonRichard B Hubbard
Jun 15, 2016·American Journal of Respiratory and Critical Care Medicine·Harold R CollardFernando J Martinez
Oct 7, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Antonella Arcadu, Teng Moua
Apr 13, 2017·Chest·Natalya AzadehJay H Ryu
Sep 29, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Yasuhiro KondohKevin K Brown

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