Treatment of acute hepatitis C with interferon alpha-2b: early initiation of treatment is the most effective predictive factor of sustained viral response

Alimentary Pharmacology & Therapeutics
J DelwaideBelgian Association for the Study of the Liver (BASL)

Abstract

To evaluate the efficacy of early interferon alpha-2b in non-post-transfusion acute hepatitis C virus: a prospective study with historical comparison. Group A: 28 patients prospectively treated for acute hepatitis C virus with daily regimen of interferon 5 million units for 2 months. Group B: historical series of 16 patients with untreated acute hepatitis C virus. There was no significant difference between the two groups with regard to gender, age, icterus, alanine aminotransferase, or genotypes. In group B, hepatitis spontaneously resolved in three of 16 (19%) patients (follow-up 1-7 years). In group A, 21 of 25 patients became sustained viral responders (75%; P = 0.0003 vs. group B). Factors include not predictive of sustained viral response: age, gender, sources of infection, presence of icterus, alanine aminotransferase peak, bilirubin peak, incubation period, presence of hepatitis C virus antibodies at presentation, or genotypes. The time from presentation to the start of therapy was, however, significantly shorter in sustained viral responders (43 +/- 31 days) than in relapsers or non-responders (88 +/- 52 days) (P = 0.016). Early treatment of acute hepatitis C virus with interferon prevents chronicity. A short waiting t...Continue Reading

References

Mar 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M BarreraA Ordinas
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S A VillanoD L Thomas
Jul 25, 2000·JAMA : the Journal of the American Medical Association·D L ThomasD Vlahov
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J RodgerN Crofts
Feb 15, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L B SeeffL Barbosa
Jan 17, 2002·The New England Journal of Medicine·E JaeckelUNKNOWN German Acute Hepatitis C Therapy Group
Jan 17, 2002·The New England Journal of Medicine·J H Hoofnagle
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alfredo AlbertiLuisa Benvegnù
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Harald HoferPeter Ferenci
Feb 15, 2003·Journal of Hepatology·Cathy RoyerFrançoise Stoll-Keller
May 16, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·T SantantonioG Pastore
Jul 10, 2003·Gastroenterology·J Tilman GerlachGerd R Pape
Dec 3, 2003·Journal of Hepatology·Anna LicataCalogero Cammà

❮ Previous
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Citations

Mar 26, 2013·The Lancet Infectious Diseases·Katja DeterdingUNKNOWN Hep-Net Acute HCV-III Study Group
Oct 10, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T SantantonioT Stroffolini
Sep 9, 2008·The Journal of Antimicrobial Chemotherapy·Johannes WiegandHeiner Wedemeyer
Apr 21, 2007·Journal of Gastroenterology and Hepatology·UNKNOWN Asian Pacific Association for the Study of the Liver (APASL) Hepatitis C Working PartyR Tateishi
Dec 27, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Dragan DelićNeda Svirtlih
Feb 22, 2011·Enfermedades infecciosas y microbiología clínica·María Martínez-RebollarMontserrat Laguno
Nov 14, 2007·Journal of Hepatology·Eva Martínez-BauerUNKNOWN Spanish Acute HCV Study Group
Jul 31, 2007·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Fumitaka NakajimaToru Inoue
Oct 10, 2012·Journal of Viral Hepatitis·F FabriziP Martin
Aug 14, 2009·Journal of Viral Hepatitis·K E CoreyR T Chung
Feb 16, 2005·Journal of Hepatology·Amany ZekryJohn G McHutchison
Aug 10, 2015·The International Journal on Drug Policy·Marianne Martinello, Gail V Matthews
Feb 26, 2008·AAOHN Journal : Official Journal of the American Association of Occupational Health Nurses·Stephanie M ChalupkaMargaret Quinn
Aug 19, 2008·Journal of Hepatology·Teresa SantantonioJ Tilman Gerlach
Feb 18, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Judith H AberleHeidemarie Holzmann
May 19, 2018·Nature Reviews. Gastroenterology & Hepatology·Marianne MartinelloGail V Matthews
May 15, 2008·The American Journal of Gastroenterology·Sanaa M Kamal
Sep 8, 2009·European Journal of Gastroenterology & Hepatology·Thierry MorinUNKNOWN Association Nationale des Hépato-gastroentérologues des Hôpitaux généraux (ANGH) Société de Pathologie Infectieuse de Langue
Jun 25, 2009·European Journal of Gastroenterology & Hepatology·Charalabos-Markos DintsiosChristian Krauth
Jan 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Johannes WiegandUNKNOWN German HEP-NET Acute HCV Study Group
Jan 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Antonio Craxì, Anna Licata
Feb 9, 2010·Expert Review of Gastroenterology & Hepatology·Thomas von HahnThomas Pietschmann
Feb 25, 2005·Antimicrobial Agents and Chemotherapy·Sabahattin KaymakogluAtilla Okten
Jun 25, 2005·Journal of Medical Virology·Christiane GérardUNKNOWN GLEVHE
Sep 12, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Kathleen E CoreyRaymond T Chung
Nov 21, 2009·The Lancet Infectious Diseases·Jodie Dionne-OdomKimberly Workowski

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