PMID: 6105441Aug 9, 1980Paper

Treatment of acute respiratory failure with low-frequency positive-pressure ventilation and extracorporeal removal of CO2

Lancet
L GattinoniG Damia

Abstract

Terminal respiratory failure was reversed in three patients with a combination of extra-corporeal CO2 removal through a membrane lung and oxygen diffusion into the diseased lungs between mechanical breaths induced at a frequency of 2-3/min. The technique seems to prevent the pulmonary barotrauma and extrapulmonary derangements caused by conventional mechanical ventilation.

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