Treatment of Adenomyosis with Subcutaneous Etonogestrel Implants: A Clinical Observational Study in 17 Patients

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Jianbo WuYilu Zou

Abstract

BACKGROUND Adenomyosis is a cause of chronic pelvic pain in women of reproductive age. The aim of this study was to investigate the effects of subcutaneous etonogestrel implantation on adenomyosis. MATERIAL AND METHODS A clinical observational study included 17 women with adenomyosis who were treated with subcutaneous etonogestrel implants and followed-up for 12 months. Imaging and clinical observations were undertaken in the 17 patients at baseline (time 0), and at 3 months, 6 months, and 12 months following subcutaneous etonogestrel implantation. The following imaging and clinical findings were compared between baseline (time 0) and 12-month follow-up: menstrual bleeding pattern, dysmenorrhea, visual analog scale (VAS) pain score, uterine volume, serum cancer antigen 125 (CA125) levels, hemoglobin, follicle-stimulating hormone (FSH) levels, luteinizing hormone levels, serum estradiol levels, and any treatment side effects. RESULTS All 17 patients treated with etonogestrel implants completed the 12-month follow-up, at which time, the mean hemoglobin level (127.08±2.56 g/L) was significantly higher compared with that at baseline (94.54±5.47 g/L; P<0.01); uterine volume, serum CA125, and VAS score for dysmenorrhea at 12 months (...Continue Reading

Citations

Feb 18, 2021·BMJ Sexual & Reproductive Health
Mar 25, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Yosuke OnoShinichiro Wada
Jun 24, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lekai NiePeihai Zhang
Oct 30, 2021·The Journal of Obstetrics and Gynaecology Research·Le-Kai NiePei-Hai Zhang
Jan 18, 2022·European Journal of Clinical Pharmacology·Kiran Kumar RathinamPriyadharshini A

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