Treatment of advanced cancer of the larynx and hypopharynx with chemoradiation

ANZ Journal of Surgery
Carolyn J FeatherstoneC J O'Brien

Abstract

To analyze the outcome of patients diagnosed with advanced cancer of the larynx and hypopharynx treated with combined chemotherapy and radiotherapy at Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia. Analysis of prospectively gathered data concerning patients treated between 1994 and 2000 in a multidisciplinary, tertiary referral head and neck service. Outcome measures were: treatment toxicity, locoregional tumour control, and disease specific survival. Among 54 eligible patients, cancer involved the larynx in 31 patients and hypopharynx in 23 and, of these, 38 (70%) completed all the scheduled treatment. Chemotherapy and radiotherapy were given sequentially in 39 patients and concurrently in 15. The median age of patients was 63 years (range 35-79 years) and all but three had clinical stage III or IV disease. There were two treatment related deaths. Disease persisted in five patients and 14 others relapsed. Overall, 11 (24%) patients have had a laryngectomy; five for persistent disease, three for local recurrence and three for treatment related complications in the absence of disease. There were 15 cancer-related deaths. Cumulative disease specific survival at 2 years was 77% for the larynx cancer group a...Continue Reading

References

Jun 13, 1991·The New England Journal of Medicine·UNKNOWN Department of Veterans Affairs Laryngeal Cancer Study GroupWilliam G Henderson
Dec 1, 1990·International Journal of Radiation Oncology, Biology, Physics·K K AngB W Brown
Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·J T ParsonsR R Million
Feb 1, 1995·Archives of Otolaryngology--head & Neck Surgery·A M SasslerG T Wolf
Apr 30, 1993·International Journal of Radiation Oncology, Biology, Physics·L J PetersR A Frankenthaler
Nov 22, 1997·International Journal of Radiation Oncology, Biology, Physics·L J Peters, H R Withers
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T G WendtA Schalhorn
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A S GardenL J Peters
Mar 4, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J CorryL J Peters
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D RischinR von Roemeling
Jul 10, 2002·New South Wales Public Health Bulletin·Marylon Coates, Elizabeth Tracey
May 20, 2003·ANZ Journal of Surgery·Francis T HallMichael A Jackson

❮ Previous
Next ❯

Citations

Jan 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Gabriela StuderChristoph Glanzmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.

© 2022 Meta ULC. All rights reserved