PMID: 6991095May 1, 1980Paper

Treatment of advanced colon cancer with 5-fluorouracil (NSC19893) versus cyclophosphamide (NSC26271) plus 5-fluorouracil: prognostic aspects of the differential white blood cell count

Cancer
R T ChlebowskiJ R Bateman

Abstract

One hundred twenty-one patients with advanced measurable adenocarcinoma of the colon were randomized for treatment with intravenous 5-fluorouracil (IV 5-FU) alone, 15 mg/kg/week vs. cytoxan, 15 mg/kg/week IV, on day 1 and 5-FU, 15 mg/kg/week IV during weeks 2--5, repeated in a six-week cycle. Age, sex, performance status, and disease free intervals, were comparable in both arms. Response frequency was 11% for treatment with 5-FU alone and 10% for treatment with combination therapy. The median survival time was significantly greater in the 5-FU-alone arm (8.4 months vs. 5.6 months, P less than 0.05). In both arms, survival was correlated with the nadir white blood count (WBC) achieved during therapy (P less than 0.02). Fourteen patients had pretreatment WBC of greater than 12,000/mm3. None of them had fever, bone marrow involvement with tumor, or recognizable infection at study entry. The 14 patients had a median survival time of 2.3 months, significantly shorter than that of patients with normal pretreatment WBC (P less than 0.05). A pretreatment lymphocyte count was available for all patients. No association between this value and either response to chemotherapy or survival time was noted. These results support the superiority...Continue Reading

References

Oct 1, 1976·Cancer·G Falkson, H C Falkson
Dec 1, 1976·British Journal of Cancer·C R Franks, Y Williams
Aug 24, 1974·Lancet·U S Kim, A E Papatestas
Aug 1, 1973·Archives of Surgery·J A McCredieR M Sutherland
Jan 19, 1963·JAMA : the Journal of the American Medical Association·J SOLOMONJ L STEINFELD

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Citations

Jan 1, 1985·Advances in Enzyme Regulation·S Eckhardt
Jun 1, 1986·The American Journal of Medicine·S P ThomsonT P Miller
Mar 1, 1985·Cancer Treatment Reviews·R T ChlebowskiJ B Block
Jan 1, 1987·Seminars in Surgical Oncology·N Kemeny

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