PMID: 6164479May 1, 1981Paper

Treatment of advanced male breast cancer

Cancer
W G KraybillD Kinne

Abstract

The modalities used to treat 27 male patients with metastatic breast cancer at Memorial Hospital from 1957--1979 are reviewed. The overall objective orchiectomy response rate was 48% (11/23). The median response was 11 months (6--96 months). The median survival in responders was 58 months, whereas the median survival in orchiectomy failures was 24 months. Four patients had estrogen receptor protein determinations (ERP). Two positive ERP patients and one borderline ERP patient responded (18--34 months). One ERP-negative patient failed orchiectomy. The number of major ablations in this series (two responses/two adrenalectomies, two failures/two hypophysectomies) does not permit conclusions, although review of the literature suggests that major ablation may be valuable in patients responding to orchiectomy. Two of three patients who refused ablative therapy responded (three months, ten months) to single agent provera. Administering stilbesterol to the ten-month responder and to the patient who failed provera resulted in two additional responses (four months, continuing, and 22 months). Of six patients who failed orchiectomy and subsequently received chemotherapy, four patients responded (7--40 months). The median survival in these...Continue Reading

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Citations

Oct 13, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·T KanohY Morishita
Apr 3, 2013·European Journal of Pharmacology·Berta SousaFatima Cardoso
Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Joerg HeinigHermann P G Schneider
Aug 1, 1996·American Journal of Clinical Oncology·U SchuchardtR Sauer
Oct 13, 1998·The Australian and New Zealand Journal of Surgery·H L CarmaltD J Gillett
Jun 19, 2008·World Journal of Surgical Oncology·Kaiyumars B ContractorHemant Singhal
Jun 10, 2010·Future Oncology·Stefano ZurridaAntuono Latronico
Aug 28, 2009·Expert Opinion on Pharmacotherapy·Teresa G Hayes
Nov 13, 2008·The Breast Journal·Ina C Nordman, David N Dalley
May 31, 2002·Expert Opinion on Pharmacotherapy·Teresa Hayes
Jan 1, 1994·Acta Oncologica·M A IzquierdoB Ojeda
Jan 6, 2011·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Leonardo Oliveira ReisUbirajara Ferreira
Sep 21, 2018·Cancer Metastasis Reviews·Roberto A Leon-FerreKathryn J Ruddy
May 12, 2009·Critical Reviews in Oncology/hematology·Laura OttiniAntonio Russo

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