Treatment of advanced uterine leiomyosarcoma with aromatase inhibitors.

Gynecologic Oncology
Roisin O'CearbhaillMartee L Hensley

Abstract

Aromatase inhibitors are sometimes used in the treatment of selected patients with uterine leiomyosarcoma (LMS), but there are few data assessing the efficacy of aromatase inhibitors in this setting. We performed a retrospective electronic medical record review of patients with uterine LMS treated with an aromatase inhibitor at Memorial Sloan-Kettering Cancer Center between 1998 and 2008. We assessed progression-free survival (PFS) and objective response among patients with measurable disease and explored the correlation of hormone receptor status with outcome. Forty patients with advanced or recurrent uterine LMS were treated with aromatase inhibitors. Thirty-four patients had measurable disease. Hormone receptor status for these patients was as follows: estrogen receptor (ER) positive-22, ER negative-9, ER unknown-3, progesterone receptor (PR) positive-10, PR negative-10, PR unknown-14. Aromatase inhibitors used were letrozole (in 74% of patients), anastrozole (21%), and exemestane (6%). Median PFS was 2.9 months (95% CI: 1.8-5.1). The 1-year PFS rate was 28% (95% CI: 11-48%) for ER and/or PR positive uterine LMS. Best objective response was partial response (PR) in 3/34 patients (9%) (all of whom were ER positive). In this p...Continue Reading

References

Dec 1, 1990·Gynecologic Oncology·K WadeM Cauchi
Oct 15, 1984·American Journal of Obstetrics and Gynecology·J T SoperD L Clarke-Pearson
Aug 1, 1983·Gynecologic Oncology·E V HanniganF N Rutledge
Jul 1, 1994·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·E G SilvaM Follen-Mitchell
Jan 19, 1999·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Y L ZhaiS Fujii
Jul 31, 2001·Best Practice & Research. Clinical Obstetrics & Gynaecology·E Podczaski, R Mortel
Oct 17, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Lev BersteinDmitry Vasilyev
May 3, 2005·Gynecologic Oncology·Sindu KanjeekalShailendra Verma
May 27, 2005·Gynecologic Oncology·Sibyl Anderson, Carol Aghajanian
Jun 27, 2006·Gynecologic Oncology·Devansu TewariBradley J Monk
Feb 3, 2007·Obstetrics and Gynecology·Riitta Koivisto-KoranderOskari Heikinheimo
Jun 5, 2007·Current Opinion in Oncology·Olaf Reich, Sigrid Regauer
Aug 2, 2007·Obstetrics and Gynecology·Mary Pat HardmanAlessandro D Santin
Sep 27, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Y F LiJ J Kavanagh
Mar 13, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·O LavieG Rennert
Sep 10, 2008·Expert Opinion on Pharmacotherapy·Giuseppe BenagianoManuela Farris

❮ Previous
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Citations

Mar 20, 2014·Nature Reviews. Clinical Oncology·Mark LinchCharlotte Benson
Sep 11, 2013·Gynecologic Oncology·Stephanie RicciAmanda Nickles Fader
May 15, 2013·International Journal of Clinical Oncology·Tze Fang WongNobuo Yaegashi
Jul 16, 2014·Clinical Sarcoma Research·Eirini ThanopoulouIan Judson
May 21, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Elena García-MartínezAntonio González-Martín
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P Reichardt
Apr 20, 2011·Current Oncology Reports·Ian M Collins, David M Thomas
Oct 19, 2013·Current Oncology Reports·Nicholas Reed
Mar 25, 2011·Expert Opinion on Drug Safety·Anneleen LintermansRobert Paridaens
Jul 15, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Martee L Hensley
Nov 25, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Mazin O HamedJ Peter A Lodge
Jan 21, 2011·European Journal of Radiology·Beatrice M Seddon, Reena Davda
Nov 25, 2014·Expert Opinion on Pharmacotherapy·Angiolo Gadducci, Maria Elena Guerrieri
Jun 20, 2015·Sarcoma·Frédéric AmantPatricia Pautier
Oct 11, 2016·Sarcoma·Heather MillerMatthew L Anderson
Jan 28, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·R R CuiJ Y Hou
Feb 9, 2018·Current Treatment Options in Oncology·Claire F Friedman, Martee L Hensley
Jul 8, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·An CoosemansFrédéric Amant
Jun 29, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Alon D AltmanPrafull Ghatage
Feb 13, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Christine GarciaRamey D Littell
Feb 7, 2019·Expert Opinion on Pharmacotherapy·Matteo TantariSimone Ferrero
Mar 22, 2019·Cancer Medicine·Yuqin ZangFengxia Xue
Mar 14, 2018·Journal of Gynecologic Oncology·Min Hyun BaekJoo Hyun Nam
Aug 15, 2013·Current Opinion in Oncology·Akiva P Novetsky, Matthew A Powell
May 21, 2014·Current Opinion in Oncology·David M HymanMartee L Hensley
Dec 9, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Suzanne GeorgeIsabelle Ray-Coquard
Nov 13, 2015·Expert Review of Anticancer Therapy·Jennifer A Ducie, Mario M Leitao
Aug 17, 2019·World Journal of Clinical Cases·Alessandro RizzoMargherita Nannini
May 31, 2019·BMJ Case Reports·Mee-Young LeeRobert G Maki
Aug 1, 2012·Expert Review of Anticancer Therapy·Eirini Thanopoulou, Ian Judson
Jan 1, 2012·American Society of Clinical Oncology Educational Book·Martee L Hensley
Sep 11, 2020·International Journal of Surgical Pathology·Michela LibertiniRobin L Jones
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Juneko E Grilley-OlsonDavid G Kirsch
Dec 21, 2017·Human Pathology·Qing ZhangJian-Jun Wei

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