Treatment of aggressive thyroid cancer with an oncolytic herpes virus

International Journal of Cancer. Journal International Du Cancer
Zhenkun YuRichard J Wong

Abstract

Although many thyroid cancers carry a favorable prognosis, there is a subgroup of patients with more aggressive histologies. Current therapies offer no significant survival benefit to patients with anaplastic thyroid carcinomas, which are considered fatal. Oncolytic herpes simplex viruses (HSVs) have potent antitumor effects against a variety of human malignancies. We assessed the activity of a replication-competent, attenuated, oncolytic HSV (NV1023) against 7 different thyroid cancers, including one papillary (NPA-187), one follicular (WRO82-1), one medullary (DRO81-1) and 4 anaplastic (DRO90-1, ARO, KAT-4C and KAT-18) cell lines. Only the follicular WRO82-1 line was resistant to NV1023 infection and cell lysis at a concentration of 5 viral pfu per cell (MOI 5). All other cell lines at MOI 5 demonstrated >95% infection in vitro at day 2 by X-gal staining and >88% cell death at day 4 by cytotoxicity assays. Even at MOI 0.1, 4 of these lines displayed complete cell death by day 7. Viral proliferation assays revealed that all of the nonfollicular cell lines supported logarithmic viral replication. Flank tumors of NPA-187, DRO81-1, DRO90-1 and ARO in athymic nude mice were treated with NV1023 (2 x 10(7) pfu). All NPA-187 tumors c...Continue Reading

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Citations

Mar 6, 2009·Gene Therapy·K N Westlund
Dec 14, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhenkun YuRichard J Wong
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shu-Fu LinRichard J Wong
Aug 14, 2008·The Journal of Clinical Endocrinology and Metabolism·Shu-Fu LinRichard J Wong
Nov 5, 2014·Journal of Experimental & Clinical Cancer Research : CR·Mingxu GuanEarl E Henderson
Sep 4, 2007·International Journal of Cancer. Journal International Du Cancer·Vincent ReidRichard J Wong
Mar 1, 2007·The Journal of Clinical Endocrinology and Metabolism·Yu-Yao HuangRichard J Wong
Feb 1, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kaitlyn KellyZiv Gil
Mar 5, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Jia-Ni WangRen-Rin Liu
Nov 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ziv GilRichard J Wong

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