PMID: 6108901Nov 1, 1980Paper

Treatment of alcohol-related liver disease with (+)-cyanidanol-3: a randomised double-blind trial

Gut
J C ColmanS Sherlock

Abstract

A randomised double-blind trial of (+)-cyanidanol-3(Catechin), 2 g/day versus placebo, was carried out in 40 patients with pre-cirrhotic alcohol-related liver disease over a three month period. Twenty received the active drug and 20 placebo; one non-compliant patient in the treatment group was withdrawn. Forty-one per cent (16/39) abstained from alcohol and showed significant improvements (P < 0.005) in mean values for serum aspartate transaminase, serum gamma glutamyl transpeptidase, and mean corpuscular volume. Ten of the 16 showed overall histological improvement on liver biopsy. Fifty-nine pr cent (23/39) continued to drink, though significantly reducing their mean daily alcohol intake (P < 0.001). No significant changes occurred in this group in mean serum enzyme values, though the mean value for mean corpuscular volume improved significantly (P < 0.01) and 16 of the 23 showed overall histological improvement. Changes occurred irrespective of treatment with Catechin which suggests that, over a three month period, this drug did not influence the course of alcohol-related liver disease.

References

Jun 14, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·M C Geokas, H Rinderknecht
Sep 15, 1971·Experientia·G CettaA A Castellani
Feb 1, 1968·The American Journal of Medicine·C S Lieber, E Rubin
Apr 18, 1968·The New England Journal of Medicine·E Rubin, C S Lieber
Feb 1, 1961·The Journal of Clinical Investigation·C S LIEBER, R SCHMID
Jan 1, 1978·Scandinavian Journal of Gastroenterology·J GalizziS Sherlock

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Citations

Jan 1, 1985·Acta Medica Scandinavica. Supplementum·M Y Morgan
Aug 25, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·K Wellington, B Jarvis
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S Lieber

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