Treatment of alcoholic liver disease

Digestive Diseases
Ina BergheimGavin E Arteel

Abstract

Alcoholic liver disease (ALD) remains a major cause of morbidity and mortality worldwide. For example, the Veterans Administration Cooperative Studies reported that patients with cirrhosis and superimposed alcoholic hepatitis had a 4-year mortality of >60% (worse than many common cancers such as breast and prostate). The cornerstone for therapy for ALD is lifestyle modification, including drinking cessation and treatment of decompensation, if appropriate. Nutrition intervention has been shown to play a positive role on both an in-patient and out-patient basis. Corticosteroids are effective in selected patients with alcoholic hepatitis, and treatment with pentoxifylline appears to be a promising anti-inflammatory therapy. Recent studies have indicated anti-TNFalpha therapy, at least for alcoholic hepatitis. Some complementary and alternative medicinal agents, such as milk thistle and S-adenosylmethionine, may be effective in alcoholic cirrhosis. Treatment of the complications of ALD can improve the quality of life and, in some cases, decrease short-term mortality.

References

Jan 1, 1979·Acta Medica Scandinavica·K WeismannV Dreyer
Feb 20, 1992·The New England Journal of Medicine·M J RamondJ P Benhamou
Jan 1, 1992·Gastroenterology·P J KearnsP Gregory
May 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T PoynardJ C Chaput
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M OellerichR Pichlmayr
Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C BodeC Bode
Jun 30, 1988·The New England Journal of Medicine·D KershenobichM Rojkind
Dec 1, 1986·Alcoholism, Clinical and Experimental Research·C J McClainS I Shedlofsky
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P GinésC Rozman
Apr 1, 1985·Digestive Diseases and Sciences·L S ValbergM J Chamberlain
Jan 1, 1985·Digestion·W DinsmoreA H Love
Mar 1, 1971·Annals of Internal Medicine·R A HelmanH J Fallon
Mar 1, 1971·Annals of Internal Medicine·T B Reynolds, H A Edmonson
Apr 1, 1995·Journal of the American College of Nutrition·M P de la MazaS Hirsch
Jun 1, 1993·Alcoholism, Clinical and Experimental Research·B HultbergA Frank
Mar 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·S HirschG Ugarte
Jun 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A AkermanA M Diehl
Feb 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O FargesH Bismuth
Oct 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C MerkelA Gatta
Aug 14, 1997·The New England Journal of Medicine·S M Riordan, R Williams
Oct 23, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E Sánchez-GóngoraJ M Mato
Dec 16, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y IimuroR G Thurman
Jan 15, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·L R PenaC J McClain
Oct 8, 1999·Journal of the American College of Nutrition·S HirschD Bunout
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MalinchocP C ter Borg
Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E CabréM A Gassull
Aug 25, 2000·European Journal of Gastroenterology & Hepatology·M Schöniger-HekeleA Gangl
Feb 15, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P S KamathW R Kim
Jan 24, 2002·Journal of Hepatology·James NeubergerKrister Hockerstedt

❮ Previous
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Citations

Aug 10, 2011·Nature Reviews. Gastroenterology & Hepatology·José Altamirano, Ramón Bataller
Sep 28, 2010·Biological Chemistry·Juliane I Beier, Craig J McClain
Jul 14, 2010·International Journal of Environmental Research and Public Health·Alejandra Miranda-MendezJuan Armendariz-Borunda
Aug 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fatiha Aliche-DjoudiOdile Sergent
Mar 8, 2014·World Journal of Gastroenterology : WJG·Fatiha Nassir, Jamal A Ibdah
Oct 6, 2015·Biomolecules·Veronica L MasseyGavin E Arteel
Oct 30, 2012·Clinics in Liver Disease·Garmen A Woo, Christopher O'Brien
Apr 26, 2011·Emergency Medicine Clinics of North America·Troy W PrivetteJames K Palma
Mar 1, 2011·Chemico-biological Interactions·Rebecca L SmathersDennis R Petersen
Dec 29, 2015·Gastroenterología y hepatología·Teresa Casanovas TaltavullMichael Herdman
Dec 29, 2007·Alcoholism, Clinical and Experimental Research·Yueming TangAli Keshavarzian
Jul 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gavin E Arteel
Dec 17, 2011·Biochimica Et Biophysica Acta·John J LemastersEduardo N Maldonado
Jul 9, 2011·Toxicology and Applied Pharmacology·Harshica FernandoG A Shakeel Ansari
Sep 17, 2011·Gastroenterology·Bin Gao, Ramon Bataller
Dec 25, 2012·Toxicologic Pathology·Banrida WahlangMatt C Cave
Jan 13, 2012·Experimental Biology and Medicine·Juliane I Beier, Gavin E Arteel
Jun 18, 2014·The American Journal of Gastroenterology·Virendra SinghRatiram Sharma
Feb 13, 2019·Alcoholism, Clinical and Experimental Research·Maiko SuzukiSumio Watanabe
Feb 5, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Paul G ThomesCarol A Casey
Sep 18, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Akiko EguchiAriel E Feldstein
May 29, 2008·Journal of Gastroenterology and Hepatology·Suzanne M de la MonteJack R Wands
Jan 13, 2009·Scandinavian Journal of Gastroenterology·Yohei Kida
May 7, 2009·Alimentary Pharmacology & Therapeutics·S M Cohen, J Ahn
Sep 30, 2009·The Mount Sinai Journal of Medicine, New York·Hui-Hui TanPaul Martin
May 11, 2011·CNS Neuroscience & Therapeutics·Philipp P LobmaierHelge Waal
Mar 29, 2014·World Journal of Hepatology·Nancy Vargas-MendozaJosé A Morales-González
Sep 30, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Francislaine Ar Lívero, Alexandra Acco
May 7, 2020·International Journal of Molecular Sciences·Krestinina OlgaPapadopoulos Vassilios
Dec 17, 2020·International Journal of Molecular Sciences·Aleksander J Nowak, Borna Relja
Mar 9, 2021·Toxicology Reports·Vetriselvan SubramaniyanAnju Das
Jun 3, 2021·Biology·Madan Kumar ArumugamKusum K Kharbanda

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