Treatment of alcoholic pancreatitis

Digestive Diseases
Roland H Pfutzer, Alexander Schneider

Abstract

Chronic pancreatitis is characterized by progressive and irreversible loss of pancreatic exocrine and endocrine function. The majority of cases in the Western world are related to alcohol consumption. Treatment of alcoholic chronic pancreatitis has been difficult, since the mechanisms of disease progression and the causes of pain are poorly understood. The conservative management of chronic pancreatitis focuses on (a) avoidance of precipitating factors such as alcohol and smoking; (b) treatment of pain, and (c) replacement of exocrine and endocrine function. There is a lack of good controlled, randomized treatment trials in alcoholic pancreatitis. However, there is good evidence that lifestyle changes, such as alcohol cessation, hamper progression of the disease. Conservative treatment of pain should be based on a stepwise approach; however, underlying causes such as pseudocysts may require endoscopic or surgical therapy. Treatment of exocrine insufficiency requires pancreatic enzyme supplementation and adjustment to several smaller meals per day, while treatment of endocrine insufficiency requires insulin treatment.

References

Dec 1, 1979·Digestive Diseases and Sciences·D Y Graham
Jan 1, 1977·Scandinavian Journal of Gastroenterology·J LindeF R Barany
Aug 1, 1990·Alimentary Pharmacology & Therapeutics·S UdenJ M Braganza
Nov 1, 1989·Diabetes Care·R J Sjoberg, G S Kidd
Jan 1, 1989·European Journal of Clinical Pharmacology·J C CuerG Bommelaer
Jun 1, 1988·Gastroenterology·D E BockmanH G Beger
Jan 1, 1987·Pancreas·A B LowenfelsC S Pitchumoni
Jan 1, 1987·Pancreas·H MiyakeI Kimura
Jan 1, 1986·Scandinavian Journal of Gastroenterology·H HalgreenH Worning
Apr 19, 1973·The New England Journal of Medicine·E P DiMagnoW H Summerskill
Feb 1, 1983·Digestive Diseases and Sciences·G Isaksson, I Ihse
Oct 1, 1982·Annals of Internal Medicine·S K DuttaB S Costa
Sep 1, 1982·American Journal of Surgery·E L Bradley
Nov 1, 1995·Gastroenterology·A G PatelH A Reber
Jan 1, 1995·Journal of Clinical Gastroenterology·G de las HerasF Pons-Romero
Jan 1, 1995·Journal of Clinical Gastroenterology·W B Strum
Jul 14, 1999·Gut·S W SchmidM W Büchler
Jan 8, 2000·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·J T HaysM C Fiore
Jun 28, 2003·Best Practice & Research. Clinical Gastroenterology·M V Apte, J S Wilson
Aug 31, 2004·World Journal of Gastroenterology : WJG·Shuo-Dong WuMin-Fei Wang
Apr 26, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Byung-Moo YooKi-Baik Hahm

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Citations

Dec 2, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Michelle A AndersonDavid C Whitcomb
Aug 11, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tania M WelzelKatherine A McGlynn
Feb 6, 2020·The American Journal of Gastroenterology·Timothy B GardnerDavid C Whitcomb
Aug 28, 2012·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Namrata SinghAnoop Saraya
Aug 11, 2020·Visceral Medicine·Rainer Christoph MikschJens Werner

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