PMID: 7527850Dec 1, 1994Paper

Treatment of alloimmune neonatal neutropenia with granulocyte colony-stimulating factor

The Journal of Pediatrics
M M GilmoreD N Korones

Abstract

Despite numerous attempts to increase the neutrophil count of infants with alloimmune neonatal neutropenia, no therapy has been consistently effective. We describe two infants with alloimmune neutropenia who had a rapid and prolonged increase in neutrophil number after treatment with granulocyte colony-stimulating factor (G-CSF). Patient 1 had antibody directed against the neutrophil antigen NA2. He received three daily doses of G-CSF, and within 2 days his neutrophil count increased from 0.350 x 10(9) to 3.584 x 10(9)/L (350 to 3584/mm3). Despite cessation of treatment the neutrophil count remained in the normal range. Patient 2 had antibody to the neutrophil antigen NA1, and received six daily doses of G-CSF. Within 4 days his neutrophil count increased from 0.477 x 10(9) to 4.320 x 10(9)/L (477 to 4320/mm3) and remained in the normal range for 11 days after the last dose of G-CSF. We recommend that treatment with G-CSF be considered for selected infants with alloimmune neutropenia.

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Citations

Feb 14, 2002·British Journal of Haematology·Thomas Lehrnbecher, Karl Welte
Apr 17, 2002·Seminars in Hematology·Jan E W Palmblad, Albert E G Kr von dem Borne
Jul 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·R L RodwellR Minchinton
May 29, 2012·Early Human Development·A Del Vecchio, R D Christensen
Sep 15, 2000·Clinics in Perinatology·R D ChristensenL M Rimsza
Mar 1, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·David M WongBrett A Sponseller
Aug 8, 2006·Journal of Korean Medical Science·Tae Hee HanKyou Sup Han
Sep 30, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Hale OrenGülersu Irken
Sep 19, 2003·Journal of Perinatology : Official Journal of the California Perinatal Association·Sandra E Juul, Robert D Christensen
Nov 25, 2004·Hematology·Nancy BerlinerThomas P Loughran
Dec 21, 2019·Journal of Paediatrics and Child Health·John DoanAtul Malhotra
Dec 13, 2002·Acta Paediatrica. Supplement·A MaheshwariD A Calhoun

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