Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice.

PloS One
Tohru HasegawaFrank M LaFerla

Abstract

Alzheimer's disease (AD) is an age-associated progressive neurodegenerative disorder with dementia, the exact pathogenic mechanisms of which remain unknown. We previously reported that homocysteic acid (HA) may be one of the pathological biomarkers in the brain with AD and that the increased levels of HA may induce the accumulation of intraneuronal amyloid-beta (Abeta) peptides. In this study, we further investigated the pathological role of HA in a mouse model of AD. Four-month-old prepathological 3xTg-AD mice exhibited higher levels of HA in the hippocampus than did age-matched nontransgenic mice, suggesting that HA accumulation may precede both Abeta and tau pathologies. We then fed 3-month-old 3xTg-AD mice with vitamin B6-deficient food for 3 weeks to increase the HA levels in the brain. Concomitantly, mice received either saline or anti-HA antibody intraventricularly via a guide cannula every 3 days during the course of the B6-deficient diet. We found that mice that received anti-HA antibody significantly resisted cognitive impairment induced by vitamin B6 deficiency and that AD-related pathological changes in their brains was attenuated compared with the saline-injected control group. A similar neuroprotective effect was ...Continue Reading

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Citations

Feb 9, 2010·The Tohoku Journal of Experimental Medicine·Takeshi Tabira
Mar 20, 2012·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Aleksandar IgnjatovićIvan Spasojević
Jun 21, 2011·Trends in Pharmacological Sciences·Jia-Min ZhuoDomenico Praticò
Apr 22, 2015·Behavioural Brain Research·Kurt R StoverRichard E Brown
Jul 23, 2014·Metabolic Brain Disease·Meihui ChenRongbiao Pi
Jun 12, 2020·Frontiers in Synaptic Neuroscience·Lara Ordóñez-Gutiérrez, Francisco Wandosell
Mar 23, 2018·International Journal of Molecular Sciences·Norimichi ShirafujiYasunari Nakamoto
Aug 4, 2020·Journal of Alzheimer's Disease : JAD·Tohru HasegawaTakeshi Tabira
Oct 22, 2020·International Journal of Molecular Sciences·Peter KaplanJan Lehotsky
Jan 23, 2021·International Journal of Molecular Sciences·Hendrik NieraadGerd Geisslinger

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Methods Mentioned

BETA
ELISA
transgenic

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