PMID: 1189756Jan 1, 1975Paper

[Treatment of anovulatory sterility using clomiphen].

Zentralblatt für Gynäkologie
K Lisse

Abstract

74 patients with anovulatory sterility were treated with clomiphene for 5 consecutive days starting on the 5th day of the cycle. The dosage was in the first course of treatment 50 mg daily. The patients, who did not conceive after this dosage, were treated with higher doses of clomiphene (100 and 150 mg daily). In 66% of the cases ovulation and in 32% (49% of induced ovulation) pregnancies were achieved. In the first treatment cycle with 50 mg/day for 5 days ovulation was obtained in 27 out of 74 patients. 14 patients, who failed to ovulate after this dosage, did ovulate after they were treated with 100 mg/day in the second treatment cycle. In 8 cases was a third treatment cycle with 150 mg/day needed to chieve a positive result. The conception rate per ovulatory cycle decreased with increasing dosage. The ovulation as judged on the basis of the temperature curve and pregnandiol excretion occured between the 4th and 25th day of treatment, whereas ovulation which were followed by pregnancy occured only between the 11th and 25th day.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.