Treatment of anxiety disorders with venlafaxine XR

Expert Review of Neurotherapeutics
Michael E Thase

Abstract

When venlafaxine was introduced in 1994, it was the first of the newer generation antidepressants to be classified as a serotonin norepinephrine reuptake inhibitor (SNRI). An extended release (XR) formulation of venlafaxine, introduced in 1997, subsequently received regulatory approval for treatment of three anxiety disorders: generalized anxiety disorder, social anxiety disorder and panic disorder. Although less extensively studied, venlafaxine XR also appears to have efficacy for two other anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder. In contrast to the treatment of depression, for which meta-analyses suggest an efficacy advantage relative to selective serotonin reuptake inhibitors (SSRIs), evidence of differential efficacy has not yet been established for any of the anxiety disorders. The overall tolerability profile of venlafaxine XR is generally comparable to that of the SSRIs, although there is greater incidence of noradrenergically mediated side effects (i.e., dry mouth and constipation), as well as a dose-dependent risk of treatment-emergent high blood pressure. Concerns about safety in overdose have also recently emerged. Despite these caveats, venlafaxine XR is an effective and g...Continue Reading

References

Sep 13, 1988·European Journal of Pharmacology·B M BaronM W Dudley
Oct 1, 1984·Archives of General Psychiatry·L N RobinsD A Regier
Feb 1, 1997·Journal of Clinical Psychopharmacology·M J Gitlin
Feb 1, 1997·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·J C Pecknold
Jan 1, 1996·Anxiety·R L DuPontH J Harwood
Jan 20, 1998·The American Journal of Psychiatry·C Salzman
Feb 26, 1998·Journal of Affective Disorders·J P FeighnerM K McPherson
Aug 24, 1999·The Journal of Clinical Psychiatry·P E GreenbergA J Fyer
May 12, 2000·Archives of General Psychiatry·A T HarveyS H Preskorn
Jun 1, 2000·The American Journal of Psychiatry·K RickelsJ T Haskins
Dec 1, 2000·Depression and Anxiety·P H Roseboom, N H Kalin
Dec 1, 2000·Depression and Anxiety·J M Gorman, L A Papp
Mar 7, 2001·The British Journal of Psychiatry : the Journal of Mental Science·M E ThaseR L Rudolph
Jul 4, 2001·The British Journal of Psychiatry : the Journal of Mental Science·C AllgulanderE Salinas
Feb 14, 2002·The Journal of Clinical Psychiatry·Robin A EmsleyDan J Stein
Apr 3, 2002·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·J D VanderkooyR Michael Bagby
May 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·David SmithIan Anderson
May 10, 2002·The Journal of Clinical Psychiatry·Anita H ClaytonAlan Metz
Jul 24, 2002·The International Journal of Neuropsychopharmacology·Andre De NayerAnnick Mignon
Oct 22, 2002·Expert Opinion on Pharmacotherapy·Ann C Schwartz, Barbara O Rothbaum
Dec 7, 2002·BMJ : British Medical Journal·Nicholas A Buckley, Peter R McManus
Feb 22, 2003·CNS Drug Reviews·Udo Bonnet
Apr 19, 2003·QJM : Monthly Journal of the Association of Physicians·I M WhyteN A Buckley
Jun 20, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·David HackettEliseo Salinas
Nov 19, 2003·Journal of Clinical Psychopharmacology·Damiaan DenysHerman G M Westenberg
Jan 2, 2004·The American Journal of Psychiatry·Mark S Bauer, Landis Mitchner
Jan 28, 2004·The Journal of Clinical Psychiatry·Damiaan DenysHerman G M Westenberg
Jan 28, 2004·Biological Psychiatry·S Neil VaishnaviMichael J Owens
Mar 9, 2004·Journal of Psychiatric Research·Jeffrey S SimonDean Lei
Apr 21, 2004·The Journal of Clinical Psychiatry·Stuart A MontgomeryUNKNOWN Venlafaxine 335 Study Group

❮ Previous
Next ❯

Citations

Jun 1, 2006·Current Psychiatry Reports·Lesley M Arnold
Nov 4, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Stuart MontgomeryFrancesca Baldinetti
Aug 2, 2008·Expert Opinion on Pharmacotherapy·Falk W Lohoff, Karl Rickels
Oct 17, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Thomas N WiseVicenzio Holder-Perkins
Mar 11, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·Stefan BegréRoland von Känel
Jul 3, 2007·Frontiers in Neuroendocrinology·Joseph S Lonstein
Apr 1, 2009·Brain Research·Lakshmi N Ravindran, Murray B Stein
Feb 9, 2018·Acta Pharmacologica Sinica·Dong-Yao WangAlbert H C Wong
Feb 21, 2007·Expert Opinion on Pharmacotherapy·Anita H Clayton
Oct 16, 2018·Pharmacological Reports : PR·Carlos Eduardo de Souza MenezesDanielle Macêdo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.