Treatment of ataxia in cortical cerebellar atrophy with the GABAergic drug gabapentin. A preliminary study

European Neurology
J GazullaCarlos J Tordesillas

Abstract

The aim of this work was to investigate the efficacy of the GABAergic drug gabapentin in the treatment of the cerebellar signs caused by cortical cerebellar atrophy (CCA). Ten patients with CCA received gabapentin in single doses of 400 mg in an open-label study; thereafter, daily administration of 900-1,600 mg of gabapentin was continued during at least 4 weeks. An ataxia scale based on clinical findings was used to evaluate the cerebellar signs at baseline and after administration of the drug. A statistically significant improvement of the ataxia scores was found after single doses of 400 mg of gabapentin and after the administration of 900-1,600 mg of this drug during 4 weeks, as compared to the results obtained at baseline. An important clinical amelioration was also evident. Gabapentin has been demonstrated to be capable of improving the cerebellar signs in cases of CCA, after single doses and after continued administration of the drug during 4 weeks. GABAergic enhancement or supplementation could play an important role in the treatment of diseases of the cerebellar cortex associated with a deficit of GABA.

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Citations

May 3, 2005·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Elena L Grigorenko
Jan 29, 2008·Journal of the Neurological Sciences·José Gazulla, Pedro Modrego
Sep 11, 2007·Acta Neurologica Scandinavica·J Gazulla, I Benavente
Feb 14, 2006·Journal of Pharmacological Sciences·Jen-Kun Cheng, Lih-Chu Chiou
Sep 15, 2009·Brain Research·Alessandro MassellaLuciana Giardino
Jan 23, 2009·Journal of the Neurological Sciences·Katsuya NakamuraShu-ichi Ikeda
Jun 12, 2014·Movement Disorders Clinical Practice·Harini Sarva, Vicki Lynn Shanker
Aug 20, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·José Gazulla
Aug 20, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·J Thaddeus Coin, Jeffery M Vance

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