PMID: 2494243Mar 15, 1989Paper

Treatment of atrioventricular node reentrant tachycardia with encainide: reversal of drug effect with isoproterenol

Journal of the American College of Cardiology
I NiaziM Akhtar

Abstract

To determine the efficacy of encainide in the treatment of atrioventricular (AV) node reentrant tachycardia, Holter electrocardiographic (ECG) monitoring, exercise treadmill testing and programmed electrical stimulation were performed in 16 patients while they were taking no medication and after steady state levels were reached during treatment with encainide (75 to 200 mg/day; mean 117 +/- 47). In addition, to study the possible reversal of drug effects by sympathetic stimulation, AV node conduction and tachycardia induction were reassessed during isoproterenol infusion (1 to 3 micrograms/min), a dose calculated to increase the rest heart rate by 25 +/- 10%. Sustained AV node reentrant tachycardia could be initiated in all 16 patients in the control state, in 2 patients after encainide and in 10 patients during isoproterenol infusion. The shortest mean atrial paced cycle length sustaining 1:1 AV conduction was 358 +/- 57 ms during the control study, which increased to 409 +/- 59 ms with encainide (p less than 0.01 versus control) and decreased to 313 +/- 31 ms during isoproterenol infusion (p less than 0.01 versus control and encainide). The shortest mean ventricular paced cycle length with 1:1 ventriculoatrial conduction was ...Continue Reading

References

Nov 1, 1979·European Journal of Clinical Pharmacology·H Kesteloot, R Stroobandt
Jul 1, 1975·American Heart Journal·G VargasA N Damato
Sep 1, 1975·The American Journal of Cardiology·M AkhtarS H Lau
Aug 29, 1986·The American Journal of Cardiology·P E Pool
Sep 1, 1970·Circulation Research·A L WitA N Damato
Sep 1, 1981·Pacing and Clinical Electrophysiology : PACE·M Akhtar
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·R W TsienM Nowycky

❮ Previous
Next ❯

Citations

May 9, 2006·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·John E O'MaraEugen C Palma
Sep 1, 1989·Journal of the American College of Cardiology·M R JazayeriM Akhtar
Feb 1, 1992·Journal of the American College of Cardiology·H CalkinsF Morady
Jun 18, 1998·American Heart Journal·R WeissF Morady
Oct 1, 1993·Journal of Basic and Clinical Physiology and Pharmacology·Y BirnbaumJ Kusniec

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.