Treatment of Axial Spondyloarthritis: What Does the Future Hold?

Current Rheumatology Reports
Denis Poddubnyy, Joachim Sieper

Abstract

To provide a summary of the recent and expected developments related to the treatment of axial spondyloarthritis. An increasing number of interleukin-17 blocking agents show efficacy in axial spondyloarthritis including both non-radiographic and radiographic forms. Janus kinase inhibitors showed promising results in phase II studies in radiographic axial spondyloarthritis and have, therefore, a potential to become a therapeutic option in this indication in the future. Inhibition of structural damage progression in axial spondyloarthritis seems to be possible in the case of effective and early anti-inflammatory treatment, although there are still open questions related to particular drug classes. Despite major advances in the field and growing therapeutic options, there are still many open questions related to the optimized treatment strategies and to the individual choice of a drug in axial spondyloarthritis.

References

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Citations

Dec 22, 2020·Therapeutic Advances in Musculoskeletal Disease·Katharina MeierKamran Ghoreschi
Mar 12, 2021·Frontiers in Immunology·Claudia SchinoccaGiuliana Guggino
Apr 29, 2021·Annals of the Rheumatic Diseases·Atul DeodharDésirée van der Heijde
Apr 29, 2021·Current Rheumatology Reports·David F L LiewPhilip C Robinson

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Clinical Trials Mentioned

NCT02758782
NCT02696031
NCT00944658
NCT03259074
NCT03043846
NCT03906136
NCT02505542
NCT03253796

Software Mentioned

ASAS

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