Treatment of BK virus-associated hemorrhagic cystitis with low-dose intravenous cidofovir in patients undergoing allogeneic hematopoietic cell transplantation

The Korean Journal of Internal Medicine
Seung-Shin LeeHyeoung-Joon Kim

Abstract

BK virus (BKV) has been associated with late-onset hemorrhagic cystitis (HC) in recipients of hematopoietic stem cell transplantation (HSCT). Cidofovir has been used at higher doses (3 to 5 mg/kg/wk) with probenecid prophylaxis; however, cidofovir may result in nephrotoxicity or cytopenia at high doses. Allogeneic HSCT recipients with BKV-associated HC are treated with 1 mg/kg intravenous cidofovir weekly at our institution. A microbiological response was defined as at least a one log reduction in urinary BKV viral load, and a clinical response was defined as improvement in symptoms and stability or reduction in cystitis grade. Eight patients received a median of 4 weekly (range, 2 to 11) doses of cidofovir. HC occurred a median 69 days (range, 16 to 311) after allogeneic HSCT. A clinical response was detected in 7/8 patients (86%), and 4/5 (80%) had a measurable microbiological response. One patient died of uncontrolled graft-versus-host disease; therefore, we could not measure the clinical response to HC treatment. One microbiological non-responder had a stable BKV viral load with clinical improvement. Only three patients showed transient grade 2 serum creatinine toxicities, which resolved after completion of concomitant calc...Continue Reading

References

Feb 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L BrugieresJ Lemerle
May 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A BediR J Jones
Mar 1, 1997·Antimicrobial Agents and Chemotherapy·G AndreiE De Clercq
Oct 23, 1997·Clinical Microbiology Reviews·E De Clercq
Dec 10, 1999·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·A AzziA Bosi
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M I González-FraileJ F San Miguel
Jun 18, 2003·The American Journal of the Medical Sciences·Mark A Perazella
Feb 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anskar Y H LeungYok-Lam Kwong
Jul 12, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hans H Hirsch
Sep 27, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ewa GorczynskaAlicja Chybicka
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra H FilipovichMary E D Flowers
Jun 16, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Simone CesaroUNKNOWN European Group for Blood and Marrow Transplantation
Dec 23, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Javid GazievGuido Lucarelli
Mar 8, 2012·The Annals of Pharmacotherapy·Melissa C Mackey
May 25, 2012·Médecine et maladies infectieuses·M SiguierJ-F Bergmann
May 29, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Robin Q H KloosMarc Bierings
Sep 14, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·H J KwonB Cho

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Citations

Jan 1, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Michael PhilippeCatherine Rioufol
Jun 28, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Ugur SahinTaner Demirer
May 6, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Lucila Nassif KerbauyFabio Pires de Souza Santos
Nov 24, 2019·Abdominal Radiology·Ajaykumar C MoraniKhaled M Elsayes
Feb 16, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Wilson LamAndrew Daly
May 26, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Laila SchneidewindWilliam Krüger
Mar 18, 2021·Reviews in Medical Virology·Zongsong WuHans H Hirsch
Jun 12, 2020·The Journal of Infection·Anastasia SaadeUNKNOWN Infectious Disease Working party of EBMT
Aug 3, 2021·European Urology Open Science·Tahsin Batuhan Aydogan, Murat Binbay

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