Treatment of blood flow abnormality using mucosal delivery of nitric oxide

Drug Delivery and Translational Research
Chi H Lee

Abstract

This review focuses on clinical application of intravaginal formulations containing nitric oxide (NO). Poly(D,L-lactic acid-co-glycolic acid)-based microparticles or nanoparticles encapsulated with nitric oxide prodrugs, such as diethylenetriamine diazeniumdiolate and S-nitrosoglutathione, have been developed for the treatment of blood flow abnormality in various diseases including diabetes. Advanced nanotechnology allows for production of novel formulations with the capability of long-term protection, preserving the integrity of the NO donors, and delivering NO in a controlled and sustained release manner at the mucosal sites. The gene expressions of MAPK and PKC in the vaginal mucosa upon exposure to microparticles were evaluated for the mechanistic study involved with blood flow changes. The blood flow changes and protein expression of the vaginal mucosa upon exposure to intravaginal formulations containing NO donors supported that NO therapy would be suitable for the treatment of blood flow abnormality. This review subsequently would help to establish a scientific foundation for clinical trials of intravaginal NO delivery systems in humans.

References

Mar 1, 1992·Pharmaceutical Research·S W KimT Okano
Dec 1, 1995·The Journal of Biological Chemistry·A C Newton
Jun 17, 1998·Life Sciences·S K SauerP W Reeh
Sep 2, 1998·European Journal of Drug Metabolism and Pharmacokinetics·R M HernádezJ L Pedraz
Jan 28, 1999·Biochemical and Biophysical Research Communications·T PersichiniG M Lauro
Aug 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·E C DempseyR O Messing
Sep 1, 2000·International Journal of Pharmaceutics·E Ruel-GariépyJ Leroux
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F GiulianoJ Bernabe
Sep 11, 2001·Drug Development and Industrial Pharmacy·G C CeschelS Rossi
Sep 14, 2001·Journal of Sex & Marital Therapy·K ParkJ H Nam
Jun 28, 2002·International Journal of Pharmaceutics·Jung Yun ChangChong-Kook Kim
Dec 11, 2002·Journal of Biochemistry·Yoshiko Akita
Aug 22, 2003·The Journal of Biological Chemistry·János PolgárGuy L Reed
Aug 1, 1959·American Journal of Obstetrics and Gynecology·C A HUNTER, H J NICHOLAS
May 25, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F SantilliF Chiarelli
Sep 1, 2004·International Journal of Pharmaceutics·Yicheng Wang, Chi H Lee
Sep 17, 2004·Endothelium : Journal of Endothelial Cell Research·Kai Chen, John Keaney
Mar 22, 2005·European Journal of Pharmacology·Milad S BitarFahd Al-Mulla
Sep 15, 2006·BMC Women's Health·Noel N KimAbdulmaged M Traish
Jan 22, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuhan LeeTae Gwan Park
Feb 14, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Ramya ChariSatya P Kunapuli
May 5, 2009·Biomaterials·Jin-Wook YooChi H Lee
Nov 13, 2009·Molecular Pharmaceutics·Sravanthi Cheeti, Chi H Lee
Oct 26, 2010·International Journal of Pharmaceutics·Jin-Wook YooChi H Lee

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