Treatment of brain metastases in patients with testicular cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
C BokemeyerH J Schmoll

Abstract

Despite improved cure rates for patients with metastatic testicular cancer with cisplatin-based combination chemotherapy, patients who develop brain metastases are generally considered to possess a poor prognosis. This report summarizes the long-term results in 44 patients with brain metastases from testicular cancer treated between 1978 and 1995 at Hannover University Medical School. Histologically, 42 patients (95%) had a nonseminomatous germ cell cancer and two patients (5%) a seminoma. Thirty-nine patients (89%) had lung metastases and 37 (84%) fulfilled the criteria for advanced disease according to the Indiana University classification even without considering the brain metastases. Eighteen patients (41%) presented with brain metastases at primary diagnosis (group 1), four (9%) developed brain metastases at relapse after a previous favorable response to combination chemotherapy (group 2), and 22 (50%) developed brain metastases during or directly after cisplatin-based chemotherapy. Chemotherapy consisted of cisplatin-based combination treatment and radiotherapy was given as whole-brain irradiation of 30 to 40 Gy and in single cases combined with a boost of 10 Gy to single lesions. Overall, 10 patients achieved long-term s...Continue Reading

Citations

Sep 17, 1998·Der Urologe. Ausg. A·J T HartmannC Bokemeyer
Oct 12, 2001·Current Oncology Reports·J S WeinbergR Sawaya
Nov 3, 2006·Expert Review of Neurotherapeutics·Jan Drappatz, Patrick Y Wen
Nov 21, 2007·Expert Review of Anticancer Therapy·Jeffrey A ForquerSimon S Lo
Apr 10, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Terukazu Nakamura, Tsuneharu Miki
Oct 16, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Darren R FeldmanThomas Powles
Mar 21, 2018·Expert Review of Anticancer Therapy·Kenrick NgConstantine Alifrangis
Mar 10, 2005·Der Urologe. Ausg. A·M KuczykJ Beyer
Oct 30, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Norio NonomuraTsuneharu Miki
Jan 1, 2008·Clinical Medicine. Oncology·Yoshiaki KinebuchiKazuhiro Hongo
Apr 11, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·R GironesUNKNOWN Spanish Germ Cell Cancer Group (SGCCG)
Apr 26, 2016·Brain Pathology·Dan Hua ZhuZhe Bao Wu
Sep 1, 2017·Porto Biomedical Journal·Ana Filipa PintoMavilde Arantes
Sep 18, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·J Classen
Dec 10, 1999·Seminars in Surgical Oncology·M F MilosevicP Warde
Nov 24, 2016·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Marcel MatzenauerBohuslav Melichar
Dec 17, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy Gilligan
Jan 31, 2020·Frontiers in Oncology·Peihang XuDingwei Ye
Aug 21, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H J SchmollUNKNOWN European Germ Cell Cancer Consensus Group
Aug 17, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F HoneckerA Horwich
Dec 19, 2003·The Urologic Clinics of North America·Manish I PatelJoel Sheinfeld
Jun 4, 2021·American Journal of Clinical Oncology·Matthieu DelayeJean-Pierre Lotz
Dec 17, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·Y NeuzilletT Lebret

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