Treatment of breast cancer with segmental mastectomy alone or segmental mastectomy plus radiation

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
D A KantorowitzK L Doane

Abstract

A retrospective review of the outcome of treatment for primary, Stage I and II breast cancer with segmental mastectomy (SGM) alone or segmental mastectomy plus postoperative irradiation (SGM + RT) at four Rochester, New York, city hospitals is reported. Between January 1971 and March 1984, 99 women were treated with SGM and 146 with SGM + RT. Groups were similar regarding significant clinical and histologic prognostic factors; they differed, however, in that the SGM group was considerably older (means = 72) than the SGM + RT group (means = 56). Among SGM patients, local and total locoregional failure was 26.44 and 35.2%, respectively. Local and total locoregional failure (7.6 and 12.4%, respectively) was significantly reduced among patients treated with SGM + RT (p less than 0.0001). Among SGM patients, there was scant advantage in enlarging the extent of resection from local excision (29.5% local failure) to wide local excision (27.3%) to quadrantectomy (22.2%). Among women receiving SGM + RT, similar rates of local failure occurred among patients receiving local excision (15.5%) and wide local excision (12.5%). By contrast, only 2.8% of those receiving quadrantectomy failed. Results are viewed as supportive of findings of NSA...Continue Reading

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Citations

Jul 1, 1996·Journal of Surgical Oncology·M NoguchiI Miyazaki
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·E ShinN Kikkawa
Mar 15, 1996·International Journal of Radiation Oncology, Biology, Physics·C A PerezM A Lockett
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Mar 13, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P ScallietP Lambin
Mar 4, 2003·Breast Cancer Research and Treatment·Maria Arsyl D De JesusAlfred L Goldson
Jun 5, 2007·World Journal of Surgical Oncology·Kalliope ValassiadouKwok-Leung Cheung
Nov 4, 1998·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T Pignon, P Scalliet
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Feb 18, 2004·The Breast : Official Journal of the European Society of Mastology·M BorgJ Norman
Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F A ViciniA Martinez

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