Treatment of Brucellosis in Guinea Pigs via a Combination of Engineered Novel pH-Responsive Curcumin Niosome Hydrogel and Doxycycline-Loaded Chitosan-Sodium Alginate Nanoparticles: an In Vitro and In Vivo Study

AAPS PharmSciTech
Fatma I Abo El-ElaH I Hosein

Abstract

Brucellosis is a common zoonotic infection, particularly in the developing world. The recommended treatment regimens for brucellosis involve the use of two medications such as doxycycline and curcumin in order to avoid relapses and prolonged use of these drugs. Doxycycline has excellent activity in the acidic phagolysosomal environment, while curcumin modulates the immune system function and macrophage activity. Due to the intracellular existence of Brucellae and the different anti-immune mechanisms of Brucella, the treatment of Brucella infection faces many limitations. The design of nanosystems is a promising treatment approach for brucellosis. The objective of this study was to design and evaluate the efficacy of in situ pH-responsive curcumin-loaded niosome hydrogel and doxycycline-loaded chitosan-sodium alginate nanoparticles as chemotherapeutic agents against brucellosis. The prepared formulae showed a spherical nano shape with a slow drug release pattern and small particle size. The prepared formulae were evaluated in vivo using Guinea pigs experimentally infected with Brucella melitensis biovar3. The prepared formula combination gave a significant high reduction rate of Brucella spleen viable count compared with that of...Continue Reading

References

Dec 1, 1983·Archives of Toxicology·D Lorke
Apr 1, 1997·Emerging Infectious Diseases·M J Corbel
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W YingJ A Jahre
Sep 3, 2002·International Journal of Pharmaceutics·Yongmei HaoKe'an Li
Apr 29, 2004·International Journal of Pharmaceutics·Sudipta Ganguly, Alekha K Dash
Nov 3, 2005·International Journal of Pharmaceutics·Ahmed S GuinediRania M Hathout
Jan 11, 2007·Journal of Clinical Immunology·Ganesh Chandra Jagetia, Bharat B Aggarwal
Jul 9, 2008·Journal of Microencapsulation·Maha NasrA A Elshamy
Oct 1, 1979·International Journal of Cosmetic Science·R M Handjani-VilaG Vanlerberghie
Dec 29, 2009·Frontiers in Bioscience (Landmark Edition)·Edurne ImbuluzquetaMaria J Blanco-Prieto
Jan 8, 2010·International Journal of Nanomedicine·Ashish RanjanRamanathan Kasimanickam
Aug 10, 2010·International Journal of Antimicrobial Agents·Javier Solera
Aug 24, 2010·Drug Discovery Today·Ranjita MisraSanjeeb K Sahoo
Oct 1, 2005·Nanotechnology·Jose Ruben MoronesMiguel Jose Yacaman
Sep 24, 2011·Annual Review of Microbiology·Vidya L AtluriRenée M Tsolis
Nov 25, 2011·Journal of Infection in Developing Countries·Ayman MareiFayza Fathey
Apr 17, 2012·Veterinary Research·María-Jesús GrillóEdgardo Moreno
Apr 27, 2012·Journal of Microbiology and Biotechnology·Eun-Jeong HeoHyang-Mi Nam
Apr 12, 2014·International Journal of Antimicrobial Agents·Nadia Abed, Patrick Couvreur
Jul 2, 2014·Veterinary Pathology·S C Olsen, M V Palmer
Jul 23, 2015·International Journal of Pharmaceutics·Dalia S ShakerMahmoud S Hanafy
May 24, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Zahid HussainShahzeb Khan
Aug 26, 2016·Polish Journal of Microbiology·Aurea I Morales-EstradaArarceli Contreras-Rodriguez
Mar 1, 2018·Drug Delivery and Translational Research·Heba F SalemKhaled R A Abdellatif

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Methods Mentioned

BETA
transmission electron microscopy
PCR

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Brucellosis (ASM)

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.

Brucellosis

Brucellosis is a bacterial infection caused by members of the genus brucella and remains one of the world's major zoonotic diseases. Discover the latest research on Brucellosis here.