Treatment of canine permeability pulmonary edema: short-term effects of dobutamine, furosemide, and hydralazine

Circulation
W D MolloyR M Prewitt

Abstract

The effects of treatment of oleic acid pulmonary edema with dobutamine, furosemide, and hydralazine on cardiopulmonary function in 24 dogs were investigated. Pulmonary capillary wedge pressure (PCWP) was adjusted to approximately 7 mm Hg; 45 min after oleic acid (0.08 ml/kg), dogs were randomly divided into a control group, in which PCWP was maintained at approximately 7 mm Hg, and into treatment groups as described above. Mean time-averaged PCWP was 2.3 mm Hg in dogs treated with dobutamine, 4.1 mm Hg with furosemide, and 4.4 mm Hg with hydralazine. Four hours of treatment with dobutamine and furosemide significantly (p less than .01) reduced accumulation of lung water compared with the control and hydralazine groups. Qs/Qt was lower (p less than .05) with dobutamine and furosemide compared with the other groups. In dogs given hydralazine, cardiac output (CO) and systemic vascular resistance (SVR) remained constant over the 4 hr treatment interval. In contrast, in all other groups, SVR increased and CO decreased (both p less than .05). The short-term pulmonary effects of the above drugs are probably explained by differences in PCWP and/or by regional pulmonary vascular effects.

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Citations

May 23, 2006·The New England Journal of Medicine·UNKNOWN National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials NetworkAndrea L Harabin
Mar 13, 2002·Critical Care Medicine·Andrew A PellettMichael G Levitzky
Dec 4, 2012·Current Opinion in Critical Care·Gregory A Schmidt
Feb 15, 2011·Journal of Veterinary Internal Medicine·S SuzukiR Tanaka
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·F A TibayanM A Matthay
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Sep 19, 2007·Expert Opinion on Emerging Drugs·Karen J Bosma, James F Lewis
Sep 13, 2011·Annals of Intensive Care·Antoine RochLaurent Papazian

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