Treatment of cat allergy with T-cell reactive peptides

American Journal of Respiratory and Critical Care Medicine
P S NormanC F Nicodemus

Abstract

We induced in allergic humans the counterpart of murine experimental T-cell tolerance. T-cell lines from cat-allergic humans were used to map T-cell epitopes for the principal allergen of cat dander, Fel d 1. Two peptides of 27 amino acids each were synthesized to contain the dominant epitopes (ALLERVAX CAT). After a safety trial, we carried out a blinded study of the dose required for efficacy. We randomly divided 95 cat-sensitive patients into placebo, 7.5 micrograms, 75 micrograms, and 750 micrograms groups. Patients received a subcutaneous injection weekly for 4 wk. Before and after treatment, patients were exposed in a room inhabited by live cats and scored by nose and lung symptoms. Baseline nasal and lung scores (+/-SEM) were 6.2 +/- 0.56 and 5.4 +/- 0.73 in the 750 micrograms group; 7.8 +/- 0.53 and 4.7 +/- 0.68 in the placebo group. Six weeks after treatment, scores adjusted for baseline differences were reduced in the 750 micrograms group: -2.3 +/- 4.9 and -2.3 +/- 0.59 compared with -0.84 +/- 0.50 and -0.85 +/- 0.62 in the placebo group. The 75 micrograms group showed intermediate effects and the 7.5 micrograms group no effect. Linear trend analysis indicated a significant dose response effect: p = 0.05 for nose and ...Continue Reading

Citations

Dec 22, 1999·Clinical Reviews in Allergy & Immunology·S B LehrerR U Sorensen
Aug 23, 2011·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·U RaapO Pfaar
Mar 15, 2002·Current Allergy and Asthma Reports·R E Esch, J Portnoy
Mar 20, 2002·Current Allergy Reports·L G Wild, S B Lehrer
Mar 15, 2002·Current Allergy and Asthma Reports·F Runa AliMark Larché
Jan 15, 2013·Current Allergy and Asthma Reports·Linda CoxMark Larche
Jun 7, 2013·Current Allergy and Asthma Reports·Melina MakatsoriMoises A Calderon
Feb 14, 2004·Methods : a Companion to Methods in Enzymology·Susanne VrtalaRudolf Valenta
Oct 19, 2002·Molecular Aspects of Medicine·Sylvia M Miescher, Monique Vogel
Feb 13, 2001·Trends in Pharmacological Sciences·C Walker, C Zuany-Amorim
Jun 30, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Adrian G Letz, Christopher W Calabria
Feb 28, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·James H DayMaureen P Briscoe
Nov 26, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Amy M Scurlock, A Wesley Burks
Sep 10, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J H Day, M P Briscoe
Sep 21, 2001·Microbes and Infection·C A Akdis, K Blaser
Nov 8, 2001·Trends in Immunology·G Wohlleben, K J Erb
Oct 14, 2003·International Immunopharmacology·Imed Ben NasserDaniel Tome
Jun 20, 2000·Allergy·C A Akdis, K Blaser
Jul 9, 2002·Allergy·U R Müller
Apr 7, 2005·Nature Medicine·Mark Larché, David C Wraith
Dec 12, 2003·Nature Reviews. Drug Discovery·Stephen T Holgate, David Broide
Mar 19, 2005·Nature Reviews. Immunology·C M Hawrylowicz, A O'Garra
Sep 26, 2006·Nature Reviews. Immunology·Mark LarchéRudolf Valenta
Jun 20, 2001·Immunology·C A Akdis, K Blaser
Jan 11, 2001·The New England Journal of Medicine·A B Kay
Jan 5, 2007·The New England Journal of Medicine·Sally M Seymour, Badrul A Chowdhury
Oct 6, 2006·The New England Journal of Medicine·Peter S CreticosUNKNOWN Immune Tolerance Network Group
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·P W Ewan
Oct 26, 1999·Allergy·A B Kay
Oct 26, 1999·Allergy·U R Müller
Mar 3, 2010·Annual Review of Immunology·Rudolf ValentaSusanne Vrtala
Jun 10, 2004·American Journal of Respiratory and Critical Care Medicine·Mark Larché, A Barry Kay
Dec 26, 2003·American Journal of Respiratory and Critical Care Medicine·Louis-Philippe Boulet
Jul 1, 1999·American Journal of Respiratory Cell and Molecular Biology·L J Rosenwasser, E W Gelfand
Jul 25, 2003·American Journal of Respiratory Cell and Molecular Biology·Michael J Holtzman

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