Treatment of central precocious puberty

Expert Opinion on Investigational Drugs
Torsten Tuvemo

Abstract

The problems of central precocious puberty (CPP) are serious enough to the patient to deserve treatment. There is a general consensus among paediatric endocrinologists that the treatment of true CPP (i.e., in children young enough to have a formal diagnosis) is indicated in many cases. In children with modestly early puberty who are not fulfilling the diagnostic criteria, this is not the case. The treatment of choice is a gonadotropin-releasing hormone (GnRH) analogue. Prolonged analogues are more effective than short-acting ones and, most importantly, independent of patient compliance. Data on agonists have accumulated over two decades and evidence of effects is rich in girls but sparse in boys. GnRH agonists are generally effective and safe drugs; the suppression of puberty is reversible and there is much information on GnRH agonists for the treatment of CPP showing very few adverse effects and the effects on final height are well documented in girls < 6 years of age. There is some (but not highly convincing) evidence for their effect on final height for those of 6 - 8 years of age and there is no evidence for an increase in final height after the age of 8 years in girls. If a decision to have treatment is taken, treatment sh...Continue Reading

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Citations

Apr 29, 2011·Reviews in Endocrine & Metabolic Disorders·Alfredo Ulloa-AguirreEric Reiter
Mar 24, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Shih-Yin ChenSteven E Marx
Mar 1, 2007·The Journal of Clinical Endocrinology and Metabolism·Erica A EugsterDavid Tierney
Jun 11, 2009·The Journal of Clinical Endocrinology and Metabolism·Wylie C HembreeUNKNOWN Endocrine Society
Sep 26, 2017·The Journal of Clinical Endocrinology and Metabolism·Wylie C HembreeGuy G T'Sjoen

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