Treatment of Cerebral Cavernous Malformations Presenting With Seizures: A Systematic Review and Meta-Analysis

Frontiers in Neurology
Xiangyu GaoXiaofan Jiang

Abstract

Background: Cerebral cavernous malformations (CCMs) presenting with seizures can be treated with neurosurgery or radiosurgery, but the ideal treatment remains unclear. Currently, there is no adequate randomized controlled trial comparing surgical treatment and radiotherapy for epileptogenic CCMs. Therefore, we conducted a systematic review and meta-analysis of available data from published literature to compare the efficacy and safety of neurosurgery and radiosurgery for epileptogenic CCMs. Methods: We performed a comprehensive search of the Ovid MEDLINE, Web of Science, PubMed, China Biological Medicine and China National Knowledge Infrastructure databases for studies published between January 1994 and October 2019. The search terms were as follows: "epilepsy," "seizures," "brain cavernous hemangioma," "cerebral cavernous malformation," "cerebral cavernous hemangioma," "hemangioma, cavernous, central nervous system." Two researchers independently extracted the data and reviewed all the articles. We compared the advantages and disadvantages of the two treatments. Results: A total of 45 studies were included in our analysis. Overall, the seizure control rate was 79% (95% CI: 75-83%) for neurosurgery and 49% (95% CI: 38-59%) for ...Continue Reading

References

Nov 11, 1991·Journal of Neurosurgery·O Del CurlingT E Craven
Jan 1, 1991·Acta neurochirurgica·H BertalanffyW Seeger
Aug 1, 1995·Journal of Neurosurgery·D S CohenR R Goodman
Aug 1, 1997·Clinical Neurology and Neurosurgery·P CappabiancaE de Divitiis
Feb 6, 1998·Journal of Neurosurgery·B KarlssonL Steiner
Feb 22, 2000·Stereotactic and Functional Neurosurgery·F BartolomeiG Pendl
Jun 2, 2001·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·A AttarN Egemen
Feb 28, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·I E SandalciogluD Stolke
Apr 16, 2002·Journal of Child Neurology·Raj D Sheth
Jun 27, 2003·Surgical Neurology·Chung-cheng WangYuan-li Zhao
Jul 12, 2003·Journal of Neurosurgery·Tiit MathiesenLars Kihlström
Apr 8, 2006·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·P FerroliG Broggi
Jul 25, 2006·Neurosurgical Focus·Issam Awad, Pascal Jabbour
Jul 25, 2006·Neurosurgical Focus·Vincenzo Antonio D'AngeloDomenico Catapano
Jul 29, 2008·Seizure : the Journal of the British Epilepsy Association·Je Young YeonSeung-Chyul Hong
Dec 23, 2008·Epilepsia·Gregory D Cascino
May 1, 2009·Neurosurgery·Bradley A GrossBernard R Bendok
Apr 8, 2010·Clinical Neurology and Neurosurgery·Peng WangHongyang Zhao
Jun 4, 2010·Expert Review of Neurotherapeutics·Joyce A CramerRichard H Mattson
Sep 3, 2010·Neurosurgical Focus·Edward A MonacoL Dade Lunsford
Sep 28, 2010·Acta neurochirurgica·Juri KivelevJuha Hernesniemi
Aug 9, 2011·Journal of Neurosurgery·Dario J EnglotEdward F Chang
Nov 3, 2011·Journal of Neurosurgery. Pediatrics·Michael HugelshoferAdrian M Siegel
Aug 27, 2013·Journal of Neurosurgery. Pediatrics·Bradley A GrossR Michael Scott
Oct 1, 2013·Clinical Neurology and Neurosurgery·Churl-Su KwonChristopher S Ogilvy
Dec 30, 2014·Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·Ge JiaYonghong Hou
Apr 4, 2015·Chinese Medical Journal·Yong-Zhi ShanGuo-Guang Zhao
May 26, 2015·Surgical Neurology International·Yoshihisa KidaMotohiro Hayashi
Sep 30, 2015·Acta neurochirurgica·Fernando L ValeSelim R Benbadis

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Cavernous Hemangioma

Cavernous hemangioma is a blood vessel defect or benign tumor that leads to leakage of blood to the surrounding tissues. This can occur in several organs including the brain, which can lead to seizures. Discover the latest research on cavernous hemangiomas here.