Treatment of childhood Hodgkin's disease with ABVD without radiotherapy

Medical and Pediatric Oncology
H BehrendtE F Van Leeuwen

Abstract

Seventeen previously untreated children with Hodgkin's disease were treated with six courses of the combination adriamycin, bleomycin, vinblastine, and DTIC (ABVD), without radiotherapy, from 1984-1987. In all patients, complete remission was attained. After a median follow-up period of 73.5 months (range 59-98 months) five patients had a relapse after 4, 5, 11, 21, and 34 months, respectively, from attainment of complete remission. In 12 patients with stages I and II, two relapses occurred. Three out of five patients with stage III and stage IV developed a relapse. Based upon these results, we conclude that ABVD might be an appropriate treatment for newly diagnosed children with Hodgkin's disease stages I and II. However, for children with stages III and IV more intensive treatment is needed. Radio-therapy should be withheld for children with refractory disease, residual disease, or relapse.

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Citations

Jan 22, 2000·Radiation Oncology Investigations·S MuwakkitM Khogali
Apr 28, 2004·Journal of Pediatric Hematology/oncology·Della L HowellLillian Meacham
Jan 4, 1998·Journal of Pediatric Hematology/oncology·R B Raney
Oct 23, 1997·Medical and Pediatric Oncology·F Sackmann-MurielR Quinteros
Jul 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Odile Oberlin
Oct 18, 2012·Journal of Pediatric Hematology/oncology·Amita TrehanRadhika Srinivasan

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