PMID: 15218425Jun 26, 2004Paper

Treatment of children with B-cell non-Hodgkin's lymphoma in developing countries: the experience of a single center in Brazil

Journal of Pediatric Hematology/oncology
Claudete Esteves KlumbJane de Almeida Dobbin

Abstract

To treat non-Hodgkin's B-cell lymphoma (B-NHL) in children with manageable toxicity-related morbidity and without any decrease in survival. Between January 1998 and April 2003, 53 consecutive patients (age 16 years or less) from a single institution were enrolled. The patients were stratified by risk factors (stage and LDH level) and treated with a BFM 86/90 (Berlin-Frankfurt-Münster)-based protocol with reduction of the methotrexate dose from 5 mg/m to 2 mg/m. The mean age of the patients was 6 years (range 1-16 years). Seventy-two percent of the patients had lymphomas classified as Burkitt type, 11% as diffuse large cell lymphoma, and 6% as Burkitt-like lymphoma, and 11% were not classified. At a median follow-up of 35 months, 44 patients (83%) survived in complete remission. The event-free survival rate for all patients was 78% (SE = 0.07): 100% (SE = 0.0) for stage I/II patients and 74% (SE = 0.08) for stage III/IV patients. Six patients suffered initial treatment failure and one patient relapsed, all of whom died. There was only one death from sepsis related to treatment. This strategy was very effective for treating B-NHL in a developing country. The results were comparable to those of the BFM 90 study and other contempor...Continue Reading

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Citations

Jul 12, 2008·Clinical and Experimental Medicine·Alex Sandro C MachadoClaudete Esteves Klumb
Aug 4, 2012·Journal of Pediatric Hematology/oncology·Carolina CervioGuillermo L Chantada
Nov 6, 2012·Revista brasileira de hematologia e hemoterapia·Keyla Christy Christine Mendes Sampaio CunhaMarcos Borato Viana
Jan 6, 2011·International Journal of Hematology·Mariana Tavares de SouzaMaria Luiza Macedo Silva
May 18, 2010·Leukemia & Lymphoma·Alex S C MachadoClaudete E Klumb
Apr 6, 2016·Annals of Hematology·Marcela Cristina RobainaClaudete Esteves Klumb
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rocio HassanHéctor N Seuánez
Feb 8, 2011·Pediatric Blood & Cancer·Maria Luisa MoletiAnna Maria Testi
Dec 4, 2014·Molecular and Clinical Oncology·Laila M SheriefRabab Elbehedy
Mar 16, 2019·Science·Catherine G LamKathy Pritchard-Jones
Apr 11, 2018·BMJ Paediatrics Open·Hugo A MartijnSaskia Mostert
Dec 7, 2021·British Journal of Haematology·Maria Luisa MoletiRobin Foà

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