PMID: 9544222Apr 17, 1998Paper

Treatment of children with relapsed soft tissue sarcoma: report of the German CESS/CWS REZ 91 trial

Medical and Pediatric Oncology
T KlingebielJ Treuner

Abstract

The present study was performed to evaluate the possibilities of relapse treatment in patients heavily pretreated for a soft tissue sarcoma. Prospective, multicenter study in 44 soft tissue sarcoma (STS) patients with first relapse. Primary diagnosis was embryonal rhabdomyosarcoma (RME) in 17 patients, alveolar rhabdomyosarcoma (RMA) in 13, primitive neuroectodermal tumor (PNET) in 6, and miscellaneous soft tissue sarcomas in 8 patients. Initial chemotherapy consisted of carboplatin/etoposide combination (150 mg/m2 each, days 1 to 4) followed by local therapy including surgical treatment and, whenever possible, radiotherapy. In 11/17 patients without primary tumor resection, CR or PR was achieved following the initial two cycles of chemotherapy (61%). The probability of event-free survival (pEFS) for RME patients was 0.41 +/- 0.12 at 5 years, and 0.25 +/- 0.12 for RMA patients. But, in contrast no PNET patient or patient with another soft-tissue sarcoma achieved long-term remission. Additional local radiotherapy significantly (P = 0.002) improved pEFS (3-year estimates of 0.23 +/- 0.2 vs. 0.1 +/- 0.1 in patients without radiotherapy). In patients with RME, relapse treatment employing a carboplatin/etoposide combination may indu...Continue Reading

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Citations

Sep 18, 2016·Annals of Surgical Oncology·Monika ScheerUNKNOWN Cooperative Weichteilsarkom Studiengruppe [CWS]
May 25, 2006·The Oncologist·Mark BernsteinHerbert Juergens
Jan 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tobias M DantonelloEwa Koscielniak
Jan 24, 2009·Pediatric Blood & Cancer·Adrian C MattkeEwa Koscielniak
Feb 19, 2013·Pediatric Blood & Cancer·Tobias M DantonelloUNKNOWN Cooperative Weichteilsarkom Studiengruppe
May 17, 2005·Cancer·Stefano MazzoleniUNKNOWN Associazione Italiana di Ematologia e Oncologia Pediatrica Soft Tissue Sarcoma Committee
Aug 10, 2011·Pediatric Blood & Cancer·Federica De CortiGiovanni Cecchetto
Nov 5, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A S PappoH E Grier
Jan 31, 2002·Paediatric Drugs·Ewa KoscielniakJörn Treuner
Oct 10, 2006·Future Oncology·Piotr Czauderna
Jul 2, 2020·OncoTargets and Therapy·Deepam PushpamBivas Biswas
Sep 22, 1999·Pathology Oncology Research : POR·B GunawanV Schumpelick
Mar 7, 2021·Journal of Clinical Medicine·Christine M Heske, Leo Mascarenhas

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