Treatment of cholangiocarcinoma complicating primary sclerosing cholangitis: the Mayo Clinic experience

The American Journal of Gastroenterology
M KayaK D Lindor

Abstract

The aims of this retrospective study were to assess the frequency with which we used different treatment modalities for patients with primary sclerosing cholangitis (PSC) and cholangiocellular carcinoma (CCA). A total of 41 patients with known CCA complicating PSC with a median age of 49 yr (range, 27-75 yr) were identified from a group of 1009 patients (4%) with PSC seen over 10 yr at the Mayo Clinic. These patients received mainly five forms of treatment: 10 patients were treated with radiation therapy (RT) with or without 5-fluorouracil (5-FU) (seven with palliative and three with curative intent), nine with stent placement for cholestasis, 12 with conservative treatment, four with surgical resection (one of four received RT and 5-FU), and three patients with orthotopic liver transplantation and RT, with or without 5-FU. One patient was treated with 5-FU alone, one with photodynamic therapy, and one patient with somatostatin analog. A total of 36 patients died, whereas four (10%) patients survived (two with surgical resection, one with orthotopic liver transplantation and RT, and one with stent placement) during a median follow-up of 5.5 months (range, 1-75 months). One patient was lost to follow-up. In highly selective case...Continue Reading

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Citations

Jun 6, 2008·World Journal of Gastroenterology : WJG·Marina-G Silveira, Keith-D Lindor
Jul 9, 2008·World Journal of Gastroenterology : WJG·Ali Shorbagi, Yusuf Bayraktar
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