PMID: 6112039May 2, 1981Paper

Treatment of chronic heart failure with pirbuterol: acute haemodynamic responses

British Medical Journal
J R DawsonG C Sutton

Abstract

Fifty-nine patients with severe chronic heart failure were given pirbuterol, a beta agonist with vasodilator and positive inotropic properties. The acute haemodynamic responses to both single (20 patients) and incremental doses (39 patients) were measured. Pirbuterol increased cardiac index and reduced left ventricular filling pressure and systemic vascular resistance with only small changes in heart rate and blood pressure. Maximal effects were observed at an average of 170 minutes after a single oral dose of pirbuterol. In the incremental dose studies the plasma pirbuterol concentration was found to increase with increasing doses and was related to the magnitude of the haemodynamic response. Pirbuterol was well tolerated, and no drug-related side effects were recorded. Oral pirbuterol clearly improved pump performance in these patients, the haemodynamic changes being consistent with vasodilatation as the dominant mechanism rather than a direct inotropic effect.

References

Jun 1, 1977·British Journal of Clinical Pharmacology·I C PatersonI W Grant
May 1, 1977·British Heart Journal·J D StonerD C Harrison
Aug 4, 1977·The New England Journal of Medicine·J N Cohn, J A Franciosa
Jul 1, 1978·Clinical Pharmacology and Therapeutics·N K Burki, L Diamond
Jul 1, 1977·British Heart Journal·K Chatterjee, W W Parmley
Oct 1, 1976·Biomedical Mass Spectrometry·F C Falkner, H M McIlhenny
Aug 1, 1975·The American Journal of Cardiology·N AkhtarM H Chaudhry
Feb 1, 1980·British Heart Journal·P D BourdillonG C Sutton

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Citations

Jan 1, 1982·Pharmacology & Therapeutics·A E Tattersfield
Jun 24, 2008·The Journal of Emergency Medicine·Carley Ann MaakDana E McClintock
Sep 29, 2000·The Journal of the Acoustical Society of America·P AvanP Bonfils
Jul 1, 1983·Medicinal Research Reviews·J A Bristol, D B Evans

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