Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized, controlled trial

The New England Journal of Medicine
G L DavisHepatitis Interventional Therapy Group

Abstract

Chronic hepatitis C (non-A, non-B hepatitis) is a common and often progressive viral liver disease. To assess the efficacy of therapy with the antiviral agent interferon alfa, we randomly assigned 166 patients with chronic hepatitis C to treatment with either 3 million or 1 million units of recombinant interferon alfa three times weekly for 24 weeks, or to no treatment. The probability of normalization or near normalization of the serum alanine aminotransferase levels after six months of interferon therapy was 46 percent in patients treated with 3 million units of interferon (P less than 0.001) and 28 percent in those treated with 1 million units (P less than 0.02), but only 8 percent in untreated patients. The serum alanine aminotransferase level became completely normal in 22 of the 26 patients (85 percent) who responded to treatment with 3 million units of interferon and 9 of the 16 patients (56 percent) who responded to treatment with 1 million units. The patients who received 3 million units of interferon had histologic improvement because of the regression of lobular and periportal inflammation. Relapse within six months after the completion of treatment occurred in 51 percent of the patients treated with 3 million units ...Continue Reading

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Citations

Apr 1, 1997·Journal of Medical Virology·M J AmaroV Carreño
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K E ShermanZ D Goodman
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E J HeathcoteL M Blatt
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May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M EnomotoT Monna
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A KasaharaK Okita
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Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T FukumaC Sato
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L Bonkovsky, J M Woolley
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T V InglesbyD L Thomas
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