Treatment of chronic osteomyelitis with a collagen-antibiotic compound--preliminary report

Unfallchirurgie
R AscherlG Blümel

Abstract

A compound of collagen and gentamicin was used in a controlled examination on 67 patients for the treatment of posttraumatic as well as postoperative osteomyelitis and, when applying cement-free endoprostheses, for hemostasis and local prevention of infection in the bed for implantation. Even in case of relatively high doses, the gentamicin concentration measured was only at the threshold value of detectability, due to the local application of the absorbable antibiotic compound. In most of all cases (n = 63), the healing of infection is demonstrated by clinical and radiobiological investigation.

Citations

Jul 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S C BudsbergJ Brown
Sep 24, 2011·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Panagiotis TsikourasAlexander Tobias Teichmann
Aug 3, 2010·The Journal of Bone and Joint Surgery. British Volume·V L L BecklesW J Harrison
Jul 20, 2011·The Journal of Bone and Joint Surgery. British Volume·H Wynn JonesW J Harrison
Feb 2, 2011·The Journal of Bone and Joint Surgery. British Volume·M El-HusseinyF S Haddad
Nov 1, 1996·The American Journal of Medicine·D W Haas, M P McAndrew

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