PMID: 11912396Mar 26, 2002Paper

Treatment of chronic prostatitis lowers serum prostate specific antigen

The Journal of Urology
Caleb B BozemanDennis D Venable

Abstract

We evaluated men with documented chronic prostatitis and elevated serum prostate specific antigen (PSA) to determine whether treatment with antibiotics and anti-inflammatory drugs lowers serum PSA. We retrospectively reviewed the records of 95 men who presented with serum PSA greater than 4 ng./ml. and were subsequently diagnosed with chronic prostatitis with greater than 10 white blood cells per high power field in expressed prostatic excretions. Patients meeting these criteria were treated with a 4-week course of antibiotics and a nonsteroidal anti-inflammatory agent. In all patients followup PSA was determined within 2 months of treatment. Mean PSA decreased 36.4% from 8.48 ng./ml. before to 5.39 after treatment (p <0.001). In 44 patients (46.3%) serum PSA decreased to below 4 ng./ml. (mean 2.48) and these patients no longer had an indication for biopsy. In the remaining 51 patients serum PSA remained elevated at greater than 4 ng./ml. and they underwent double sextant transrectal ultrasound guided biopsy. Pathological study showed prostate cancer in 13 cases (25.5%), chronic inflammation in 37 (72.5%) and only benign prostatic hypertrophy in 1 (1.05%). PSA in the 13 patients with prostate cancer decreased with treatment onl...Continue Reading

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Citations

Jun 28, 2005·Current Urology Reports·Puneet Sindhwani, Christopher M Wilson
Apr 25, 2006·Current Urology Reports·Timothy C BrandJoseph W Basler
Sep 4, 2008·Current Urology Reports·Jaspreet S Sandhu
Jul 20, 2007·Prostate Cancer and Prostatic Diseases·V SerrettaD Melloni
May 26, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·W F S BusatoF S Busato
Oct 29, 2009·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Avraham ShtrickerGabriel Gillon
Mar 31, 2004·The Medical Clinics of North America·Misop HanWilliam J Catalona
Mar 31, 2004·The Medical Clinics of North America·Vi N Hua, Anthony J Schaeffer
Jan 31, 2006·Urology·Robert B NadlerUNKNOWN Chronic Prostatitis Collaborative Research Network
Dec 15, 2004·Urology·Jun KawakamiJ Curtis Nickel
Aug 8, 2006·The Journal of Urology·Gregory T MacLennanSanjay Gupta
Nov 18, 2008·The Journal of Urology·Sümer BaltaciYaşar Bedük
Jul 7, 2009·Nature Reviews. Urology·David UlmertHans Lilja
Feb 6, 2010·The Prostate·Amit M AlgotarSteven P Stratton
Jun 29, 2010·Current Opinion in Urology·J Stephen Jones
Oct 30, 2010·Korean journal of urology·Yong Hyeuk ChoiIn Rae Cho
Jul 16, 2011·The Prostate·Virginie Vlaeminck-GuillemPatrice Sednaoui

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