PMID: 2579192Feb 1, 1985

Treatment of chronic type B hepatitis with multiple ten-day courses of adenine arabinoside monophosphate

Journal of Medical Virology
J H HoofnagleS Straus


Ten patients with chronic type B hepatitis were treated with three courses of adenine arabinoside monosphosphate (Ara-AMP). The drug was given intramuscularly at a dosage of 10 mg/kg/day in ten-day courses during each of three sequential months. The patients were all men, aged 31-61 years, who were known to have had chronic hepatitis for one to four years. Each of the ten-day courses of Ara-AMP was accompanied by a marked inhibition in the serum levels of hepatitis B virus (HBV) DNA and DNA polymerase activity. However, HBV-DNA remained detectable in every patient during treatment and invariably rebounded to pretreatment levels soon after each course was stopped. One patient developed severe, and two patients developed mild neuromuscular side effects. During a 12-18-month follow-up period, only one of the ten patients has had a sustained clinical, serum biochemical, and serological remission. In this patient, serum HBeAg, HBV-DNA, and DNA polymerase became undetectable three months after the final course of treatment; serum aminotransferase levels subsequently fell into the normal range; and a follow-up liver biopsy showed a diminution in the chronic inflammatory cell activity and a disappearance of intrahepatic hepatitis B cor...Continue Reading


Apr 21, 1978·JAMA : the Journal of the American Medical Association·R B PollardW S Robinson
Jan 5, 1979·JAMA : the Journal of the American Medical Association·S L SacksW S Robinson
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Oct 1, 1981·The Journal of Infectious Diseases·J K PreiksaitisD L Tyrrell
Nov 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H HoofnagleK Ishak
Jan 1, 1982·Journal of Medical Virology·M BerningerJ L Gerin
Jun 1, 1981·Annals of Internal Medicine·J H HoofnagleZ B Bales


Mar 1, 1994·International Journal of Immunopharmacology·K B HahmE Deschamps de Paillette
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