Treatment of chronically infected open mastoid cavities with medical honey: a randomized controlled trial

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Darius HenatschRobert J Stokroos

Abstract

To investigate the efficacy of medical honey as topical treatment of chronically discharging open mastoid cavities in comparison with conventional eardrops. Single-center, prospective, randomized controlled, double-dose trial of 12 weeks. Twenty-eight patients diagnosed as having a chronically discharging open mastoid cavity underwent medical honey gel (intervention) or conventional eardrops (control) treatment. Treatment interventions were repeated after 4 weeks. Visual analogue scale of ear complaints, cavity inflammation, and bacterial infection. Most patients had a cavity with localized granulation. After treatment, inflammation score decreased in both groups (p < 0.05), with more pronounced inflammation-free cavities in the honey group. Honey treatment resulted in less discomfort (p < 0.001) and otorrhea (p < 0.001), even after correction for additional medication use (p < 0.05, p < 0.01). This decrease was not seen in the control group. Pain and itching did not change on treatment. Most cavities were infected with Pseudomonas species and Staphylococcus aureus. After treatment, a 23% increase of negative culture was seen with honey compared with 30% in the control group (nonsignificant). No serious adverse reactions were f...Continue Reading

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Citations

Jul 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Anna FrancisDavid W Johnson
Dec 7, 2018·The Annals of Otology, Rhinology, and Laryngology·Theresa TharakanRaluca Tavaluc
Jan 26, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Maurizio BattinoTamara Forbes-Hernández

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