Treatment of Class III furcation defects with expanded polytetrafluoroethylene membrane associated or not with anorganic bone matrix/synthetic cell-binding peptide: a histologic and histomorphometric study in dogs

Journal of Periodontology
Virgílio M RorizMárcio F M Grisi

Abstract

Up until now, no predictable periodontal regeneration of Class III furcation defects has been demonstrated after treatment with different available techniques. Recently, a bone graft enriched with a peptide was developed and has shown satisfactory results when applied in intrabony defects. The aim of this study was to compare the use of expanded polytetrafluoroethylene (ePTFE) membrane associated (test group) or not (control group) with anorganic bovine-derived bone matrix (ABM)/synthetic peptide, in the treatment of Class III furcation defects in dogs. Six mongrel dogs were used in this study, and the second and fourth mandibular lower premolars were extracted. Class III furcation defects were surgically created in the third premolars and filled with impression material. Afterwards, the defects were surgically assessed for debridement and root planing. Teeth were randomly assigned into test and control groups. The membranes were removed after 4 weeks, and the animals were sacrificed 12 weeks later. Comparisons between groups by the Wilcoxon signed rank test showed no statistically significant differences in the parameters evaluated. In the control group, a new bone area (NBA) of 41.71%+/-24.07%, connective tissue area (CTA) of...Continue Reading

References

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Citations

Aug 21, 2010·Journal of Periodontology·Patricia Garani FernandesMarcio Fernando de Moraes Grisi
Sep 3, 2011·Biomaterials·Emily C Carlo ReisJohn E Davies
Jul 10, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fa-Ming ChenYan Jin
Jul 30, 2008·Journal of Clinical Periodontology·Vanessa C da SilvaJoni A Cirelli
Feb 16, 2012·Journal of Clinical Periodontology·Fabricia Ferreira SuaidEnilson Antônio Sallum
May 17, 2012·Acta Odontologica Scandinavica·Emily Correna Carlo ReisTatiana Borges Carvalho
Aug 11, 2017·Tissue Engineering. Part C, Methods·Karim M Fawzy El-Sayed, Christof E Dörfer
Mar 21, 2019·Periodontology 2000·Enilson A SallumAntonio W Sallum
Jun 18, 2010·The Open Dentistry Journal·Xavier StruillouPierre Layrolle

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