Treatment of cocaine-alcohol dependence with naltrexone and relapse prevention therapy

The American Journal on Addictions
J M SchmitzJ Grabowski

Abstract

This study evaluates whether patients with cocaine-alcohol dependence might benefit from naltrexone (NTX) pharmacotherapy when delivered in conjunction with psychotherapy. Eighty outpatients meeting DSM-IV criteria for alcohol and cocaine dependence were randomly assigned to receive NTX (placebo or 50 mg/d) combined with psychotherapy (Relapse Prevention [RP] or Drug Counseling [DC]) for twelve weeks. It was hypothesized that the skills training focus of RP therapy, in combination with NTX 50 mg/d, would produce greater reductions in cocaine and alcohol use. Outcome measures included self- and objective reports of substance use, treatment retention, medication compliance, and adverse effects. During the first four weeks of treatment, the percentage of cocaine-positive urine screens was significantly lower for those receiving RP therapy (22%) than those receiving DC (47%); however, this difference subsequently diminished. No medication effects were found. All groups reported less alcohol use at the end of treatment. Treatment retention was the same among the groups, with about 33% of the subjects completing all twelve weeks of treatment. The active medication group showed better medication compliance, while the number of adverse...Continue Reading

Citations

Jul 11, 2006·Journal of Consulting and Clinical Psychology·Vivian M GonzalezKatherine A DeLaune
Oct 25, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nitya Jayaram-LindströmJohan Franck
Apr 28, 2006·Current Opinion in Psychiatry·Frank J Vocci, Ahmed Elkashef
May 19, 2007·Addiction Biology·Antonio Preti
Mar 7, 2007·CNS Drugs·George A KennaRobert M Swift
Jul 28, 2009·La Presse médicale·Jérôme LacosteNicolas Ballon
Aug 1, 2007·Journal of Substance Abuse Treatment·Helen M PettinatiCharles P O'Brien
Dec 19, 2006·Journal of Substance Abuse Treatment·James Shearer
Sep 25, 2014·The American Journal on Addictions·Helen M PettinatiCharles P O'Brien
Mar 30, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Julia M A SinclairDavid S Baldwin
Aug 9, 2005·Pharmacology & Therapeutics·Frank Vocci, Walter Ling
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
May 26, 2012·Journal of Psychopharmacology·A R Lingford-HughesUNKNOWN British Association for Psychopharmacology, Expert Reviewers Group
Apr 7, 2007·Current Opinion in Psychiatry·Sawitri Assanangkornchai, Manit Srisurapanont
Jun 13, 2018·Frontiers in Psychiatry·Bethania Mongi-BragatoLiliana M Cancela
Jun 12, 2019·Journal of General Internal Medicine·Brian ChanDevan Kansagara

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