Treatment of complicated henoch-schönlein purpura with mycophenolate mofetil: a retrospective case series report.

International Journal of Rheumatology
A A NikibakhshL Gholizadeh

Abstract

Background. Henoch-Schönlein purpura (HSP) is the most common childhood vasculitis with an incidence of approximately 10 per 100 000 children. There is some evidence to support steroid therapy in the treatment of severe abdominal pain, severe nephritis, and central nervous system involvement. However, the routine use of corticosteroids is controversial. Frequent relapses, lack of response to steroid, steroid dependency, and steroid side effects may occur in some patients. Mycophenolate mofetil (MMF) gains increasing popularity in the treatment of autoimmune disorders, but hitherto, the available evidence to support the use of MMF in HSP is limited to some case study reports. Case Presentation. We report six children with HSP who failed to respond to systemic steroid therapy, whereas MMF successfully treated the manifestations of the disease. Conclusion. The manifestations of HSP disappeared mainly during the first week of treatment with MMF and all the patients were in a complete remission at the end and after discontinuation of the therapy. In our experience, MMF appeared to be safe and effective for the maintenance of remission in the HSP patients.

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Citations

Nov 15, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yue DuYubin Wu
Oct 25, 2011·Lancet·Henry G ChengSoma Wali
Oct 26, 2012·Case Reports in Rheumatology·Mekdess AbebeEdward P Nord
Nov 16, 2018·Pediatric Rheumatology Online Journal·Courtney B CrayneRandy Quentin Cron
May 19, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Zhihong LuCaiyun Wang
Oct 31, 2020·Case Reports in Pediatrics·George NaifaElpis Mantadakis
Jul 10, 2020·La Presse médicale·Robert G Micheletti, Christian Pagnoux
Jul 2, 2021·Current Rheumatology Reports·Joana Martins-MartinhoCristina Ponte

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Methods Mentioned

BETA
biopsy
ESR

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