PMID: 18404128Apr 12, 2008Paper

Treatment of conjunctival squamous neoplasias with interferon alpha 2ab

Journal français d'ophtalmologie
Valentín Huerva, Irene Mangues

Abstract

The classical approach to the treatment of squamous neoplasias of the ocular surface is based on surgical resection and cryotherapy. High rates of recurrence have been demonstrated if the margins are not free after the resection. Primary or adjuvant chemotherapy with mitomycin C (MMC) or 5-fluorouracil has been employed to treat these neoplasias, but severe side effects on the ocular surface have been described. Interferon (INF) alpha 2b is less toxic to the ocular surface. The experience in the treatment of conjunctiva-cornea intraepithelial neoplasia (CIN) with topical or intralesional INF alpha 2b is based on isolated cases or very short series. In this report, we review the published studies and include our personal experience. The safety and effectiveness of INF alpha 2b in the treatment of primary and recurrent cases of CIN are described. The absence of serious side effects after topical administration of INF alpha 2b leads to the recommendation of this modality of therapy for primary and recurrent cases of CIN.

References

May 1, 1995·Survey of Ophthalmology·G A Lee, L W Hirst
Sep 1, 1994·Archives of Ophthalmology·S L Maskin
Feb 15, 1994·American Journal of Ophthalmology·J Frucht-Pery, Y Rozenman
Jan 23, 1998·American Journal of Ophthalmology·F R HuS H Kuo
Jan 24, 1998·American Journal of Ophthalmology·M W WilsonS A Madreperla
Mar 5, 2002·Ophthalmology·Joseph Frucht-PeryJacob Pe'er
Jul 26, 2002·American Journal of Ophthalmology·Barry A SchechterLewis Starasoler
Jul 16, 2003·Archives of Ophthalmology·Kenneth E MorgensternLee A Wiley
May 6, 2004·American Journal of Ophthalmology·Blonie W Dudney, Monika A Malecha
Jul 20, 2004·The British Journal of Ophthalmology·R GuthoffA Zettl
Aug 18, 2004·Journal of Cataract and Refractive Surgery·Shu-Wen Chang
Jul 28, 2005·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·T A FuchslugerD Meller
Aug 23, 2005·The British Journal of Ophthalmology·S EsquenaziE Holley
Oct 3, 2006·American Journal of Ophthalmology·David J Holcombe, Graham A Lee

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Citations

Nov 26, 2013·Archivos de la Sociedad Española de Oftalmología·E MataM L González
Apr 23, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·José Enrique Muñoz de Escalona RojasRosa María Bellido Muñoz
Jan 15, 2016·Ocular Immunology and Inflammation·Valentín HuervaFelip Vilardell
Mar 14, 2012·Ocular Immunology and Inflammation·Ece Turan-VuralSuphi Acar
Dec 3, 2014·Ophthalmology·Afshan A NanjiCarol L Karp
Aug 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pakama MahlumbaViness Pillay
Jun 5, 2018·Cornea·Claudine BelleriveArun D Singh
Apr 6, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Natalia LewczukJoanna Bogusławska
May 5, 2016·BioMed Research International·Marina Jovanović, Zoran Golušin
Feb 12, 2017·Expert Review of Ophthalmology·Ibrahim O Sayed-AhmedCarol L Karp

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