Treatment of COVID-19 Pneumonia: the Case for Placenta-derived Cell Therapy.

Stem Cell Reviews and Reports
Ekaterine BerishviliJonas Mattsson

Abstract

Nearly 500'000 fatalities due to COVID-19 have been reported globally and the death toll is still rising. Most deaths are due to acute respiratory distress syndrome (ARDS), as a result of an excessive immune response and a cytokine storm elicited by severe SARS-CoV-2 lung infection, rather than by a direct cytopathic effect of the virus. In the most severe forms of the disease therapies should aim primarily at dampening the uncontrolled inflammatory/immune response responsible for most fatalities. Pharmacological agents - antiviral and anti-inflammatory molecules - have not been able so far to achieve compelling results for the control of severe COVID-19 pneumonia. Cells derived from the placenta and/or fetal membranes, in particular amniotic epithelial cells (AEC) and decidual stromal cells (DSC), have established, well-characterized, potent anti-inflammatory and immune-modulatory properties that make them attractive candidates for a cell-based therapy of COVID19 pneumonia. Placenta-derived cells are easy to procure from a perennial source and pose minimal ethical issues for their utilization. In view of the existing clinical evidence for the innocuousness and efficiency of systemic administration of DSCs or AECs in similar co...Continue Reading

References

Feb 25, 2005·Investigative Ophthalmology & Visual Science·Haochuan LiHassan Alizadeh
May 12, 2010·American Journal of Reproductive Immunology : AJRI·Shigeru SaitoMika Ito
Jun 7, 2011·American Journal of Obstetrics and Gynecology·Patricia VosdoganesTimothy J M Moss
Feb 25, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·N G FairbairnR W Redmond
May 20, 2015·Immunology Letters·Paola VaccaMaria Cristina Mingari
Jul 12, 2016·Journal of Tissue Engineering and Regenerative Medicine·Marta MagattiOrnella Parolini
Mar 14, 2018·Stem Cells Translational Medicine·Olle RingdenBehnam Sadeghi
Mar 23, 2018·Cell Transplantation·Marta MagattiOrnella Parolini
Apr 25, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Behrouz FarhadihosseinabadiHassan Niknejad
Jun 3, 2018·Cell Stem Cell·Jacques Galipeau, Luc Sensébé
Nov 13, 2018·Journal of Thoracic Disease·Shahd HorieClaire H Masterson
Jun 8, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Behnam SadeghiOlle Ringdén
Jul 31, 2019·International Journal of Molecular Sciences·Andrea Olmos-OrtizVerónica Zaga-Clavellina
Aug 6, 2019·Frontiers in Immunology·Nabila Jabrane-Ferrat
Sep 24, 2019·Current Research in Translational Medicine·L L LiauJ X Law
Oct 5, 2019·Nature Communications·Fanny LebretonEkaterine Berishvili
Nov 28, 2019·Stem Cells Translational Medicine·Atul MalhotraEuan M Wallace
Mar 19, 2020·The New England Journal of Medicine·Bin CaoChen Wang
Mar 21, 2020·Lancet·Puja MehtaUNKNOWN HLH Across Speciality Collaboration, UK
Mar 25, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Dandan Wu, Xuexian O Yang
Mar 31, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Wen ZhangShuyang Zhang
Apr 3, 2020·Fetal and Pediatric Pathology·Mojgan Karimi-ZarchiReza Bahrami
Apr 8, 2020·The Journal of Clinical Investigation·Evan M BlochAaron Ar Tobian
Apr 14, 2020·Journal of Pharmaceutical Analysis·Xiaowei LiShemin Lu
Apr 20, 2020·Journal of Infection and Public Health·Zhoujie PengYuan Shi
Apr 25, 2020·Nature Medicine·Waradon SungnakUNKNOWN HCA Lung Biological Network
May 1, 2020·Proceedings of the National Academy of Sciences of the United States of America·Xiaoling XuHaiming Wei
May 27, 2020·Stem Cells Translational Medicine·Anna CargnoniOrnella Parolini

❮ Previous
Next ❯

Citations

Dec 31, 2020·Genes·Paz de la Torre, Ana I Flores

❮ Previous
Next ❯

Methods Mentioned

BETA
scRNA-seq

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.