Treatment of Cushing's disease by transsphenoidal, pituitary microsurgery: prognosis factors and long-term follow-up

Journal of Endocrinological Investigation
F BakiriM Benmiloud

Abstract

Transsphenoidal pituitary microsurgery is considered as the best treatment of Cushing's disease. However, some recent studies reported disappointing results, leading their authors to suggest the possibility of returning to a first line adrenalectomy treatment. The aim of this study was to evaluate long-term results of transsphenoidal surgery in Cushing's disease, with special interest in factors that could affect the surgical outcome on the one hand and particular attention to surgical endocrine effects on the other. Fifty consecutive patients (34 females, 16 males, mean age 29.64 +/- 1.52 yr) were studied. The median post-operative follow-up was 71.5 months (range 25-219). Clinical, biological, surgical and pathological data between the success and failure groups were compared. Criteria of cure were: normal urinary free cortisol excretion, circadian cortisol rhythm and low dose dexamethasone test. Recovery of corticotroph and somatotroph functions were followed using the insulin test. Particular attention is given to clinical evolution in evaluating other pituitary functions. T4 or FT4, prolactin, E2 in women, testosterone in men, were measured. TRH and LHRH tests were not systematically performed. Only two parameters differed...Continue Reading

References

Aug 1, 1992·The Journal of Clinical Endocrinology and Metabolism·C GicquelX Bertagna
Jun 1, 1991·Clinical Endocrinology·A B Atkinson
Sep 15, 1988·Annals of Internal Medicine·T J MampalamC B Wilson
May 1, 1986·Journal of the Royal Society of Medicine·R FahlbuschO A Müller
May 1, 1988·The Journal of Clinical Endocrinology and Metabolism·B GuilhaumeF Girard
Sep 15, 1988·Annals of Internal Medicine·J C Melby
Nov 1, 1987·The Journal of Clinical Endocrinology and Metabolism·P C AvgerinosG B Cutler
Sep 1, 1986·Acta Endocrinologica·M TagliaferriP Loli
Feb 1, 1987·Journal of Neurosurgery·W F ChandlerG Ibarra-Perez
May 1, 1986·Archives of Internal Medicine·J W Findling, J B Tyrrell
Nov 1, 1980·The Journal of Clinical Endocrinology and Metabolism·T SudaK Shizume
Jul 1, 1981·The Journal of Clinical Endocrinology and Metabolism·A KuwayamaN Kanie
Apr 5, 1984·The New England Journal of Medicine·D M StyneF A Conte
Dec 1, 1984·Clinical Endocrinology·C G SempleG M Teasdale
Nov 1, 1983·Clinical Endocrinology·J P Thomas, S H Richards
Jan 1, 1994·The Journal of Clinical Endocrinology and Metabolism·M A MagiakouG P Chrousos
Sep 1, 1993·Clinical Endocrinology·D R McCanceA B Atkinson
Jan 1, 1993·Clinical Endocrinology·D R McCanceA B Atkinson

❮ Previous
Next ❯

Citations

Jun 9, 2005·European Journal of Endocrinology·Helen L StorrMartin O Savage
Jan 2, 2008·European Journal of Endocrinology·F CastinettiT Brue
May 31, 2001·Clinical Endocrinology·G H CheeP Kendall-Taylor
Jan 10, 2008·Clinical Endocrinology·Daniella Jesus Patrick Carminatti RomanholiLuiz Roberto Salgado
Sep 20, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Maria FleseriuUNKNOWN AACE Neuroendocrine and Pituitary Scientific Committee *
Nov 4, 2000·Journal of Neurosurgery·J M SheehanE R Laws
Jan 5, 2008·Journal of Neurosurgery·Bernd Markus HofmannRudolf Fahlbusch
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Guilherme RollinMauro A Czepielewski
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Mauro A CzepielewskiNelson P Ferreira
Feb 9, 2011·Nature Reviews. Endocrinology·Nicholas A TritosBrooke Swearingen
May 30, 2019·Neurosurgery·William T BurkeEdward R Laws
Jul 13, 2019·Journal of Neurosurgery·Diogo CordeiroJason Sheehan
Jun 13, 2015·Endocrine Reviews·Rosario PivonelloAnnamaria Colao
Jun 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Nader PouratianEdward R Laws
Dec 8, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Nalini S ShahPadmavathy Menon
Jun 28, 2001·Current Problems in Surgery·J A NortonH N Le

❮ Previous
Next ❯

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