PMID: 15235531Jul 6, 2004Paper

Treatment of cutaneous human papilloma virus, poxvirus and herpes simplex virus infections with topical cidofovir in HIV positive patients

Annales de dermatologie et de vénéréologie
L Toutous-TrelluM Pechère

Abstract

Cidofovir (Vistide) is an antiviral marketed for the treatment of cytomegalovirus retinitis. Clinical efficacy has been reported with its broad antiviral spectrum that includes poxvirus, human papilloma virus and Herpes simplex. In immunodepressed patients, these infectious dermatoses are often recurrent and resistant. In an open study, we assessed the efficacy and clinical tolerance of cidofovir gel at 1 p. 100. Twelve HIV-infected adults were included. Cidofovir gel at 1 p. 100 was applied directly on the lesions, once a day, for two weeks on the molluscum and condylomas, four weeks on the warts and one week on the chronic herpes. Four patients presented with warts and 3 of them with verruca plana. In 2 of the verruca plana patients, regression was complete although relapse was observed. Two failures were noted. Local application of the gel was not tolerated by one patient suffering from condylomas of the penis. Four patients presented with molluscum contagiosum. Two complete regressions with strong local reaction and two partial regressions were observed. The latter two patients exhibited severe immunodepression, one of them subsequently received infusions of cidofovir. Two women suffering from vulvar and perianal herpes res...Continue Reading

References

Apr 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R SnoeckE De Clercq
Oct 23, 1997·JAMA : the Journal of the American Medical Association·E J ZabawskiC J Cockerell
Nov 12, 1998·Journal of the American Academy of Dermatology·E J Zabawski, C J Cockerell
Nov 13, 1998·Dermatology : International Journal for Clinical and Investigative Dermatology·M PechèreJ Krischer
Jun 22, 1999·Lancet·E G DaviesJ Harper
Jul 9, 1999·Reviews in Medical Virology·S SafrinH S Jaffe
Feb 19, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·W PreiserN S Brink
Mar 22, 2001·The British Journal of Dermatology·V DescampsC Leport
Jul 11, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·D Calista
Mar 13, 2002·Transplantation·B BienvenuC Lebbé
Aug 14, 2002·The British Journal of Dermatology·D Calista
Aug 15, 2002·International Journal of Pharmaceutics·S SantoyoM J Blanco-Príeto

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Citations

Oct 6, 2012·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M GuérinL Martin
Sep 8, 2011·Antiviral Research·Erna Geessien KroonGiliane de Souza Trindade
Feb 5, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·David C Collette, Marc A Zechel
Nov 9, 2010·Journal of the American Academy of Dermatology·Odile WautersArjen F Nikkels
Apr 19, 2008·Annales de dermatologie et de vénéréologie·D BeaulieuN Dupin
Jan 24, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·S BriandJ F Stalder
Jul 4, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·C R SimsA Safdar
Aug 2, 2014·Dermatologic Therapy·Laura Padilla EspañaMagdalena de Troya
Jan 18, 2014·Dermatologic Therapy·Laura Padilla EspañaMagdalena de Troya Martín
Aug 27, 2013·The Lancet Infectious Diseases·Xiaoying ChenJoachim J Bugert
Sep 24, 2020·International Journal of Dermatology·Lucía Quintana-CastanedoPedro Herranz-Pinto
Jul 1, 2021·JAAD Case Reports·Christina D EnescuMeena Moossavi

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