Treatment of cutaneous lupus erythematosus: current practice variations

Lupus
A ReichJ C Szepietowski

Abstract

The treatment of cutaneous lupus erythematous (CLE) remains a challenge. Most of the therapeutic options used in CLE have not been tested in randomized controlled studies and to date no agent has been approved. Therefore, CLE treatment is mostly based on personal experience. To better characterize therapeutic habits among physicians treating CLE patients, a questionnaire-based study about various aspects of topical and systemic treatment for CLE has been performed. The questionnaire was distributed among CLE experts, mostly from Japan, the USA, and Europe. A total of 82 completed questionnaires were assessed. High-potent and potent corticosteroids as well as calcineurin inhibitors were the most often recommended topical treatment for all CLE subtypes. The most relevant factors for initiation of systemic therapy were severity of skin lesions, concomitant involvement of internal organs, CLE subtype and lack of response to topical therapies. Corticosteroids and antimalarials were considered as the most suitable and effective systemic drugs for CLE patients. However, significant differences were observed between various CLE subtypes and between different countries regarding the assessment of various topical and systemic treatment o...Continue Reading

References

Apr 1, 1981·Journal of the American Academy of Dermatology·J N Gilliam, R D Sontheimer
Aug 18, 2009·The British Journal of Dermatology·G B E JemecT Ruzicka
Feb 18, 2014·Journal of the American Academy of Dermatology·Lauren OkonVictoria Werth

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Citations

Aug 18, 2018·Expert Opinion on Biological Therapy·Oshrat E Tayer-ShifmanZahi Touma
May 23, 2019·Journal of Neurology·Antoine SoulagesStéphane Mathis
Jul 28, 2020·Frontiers in Immunology·Colton J GarelliJillian M Richmond
Jul 7, 2018·Journal of Immunology Research·Matteo SaccucciAntonella Polimeni
Jun 9, 2016·Current Opinion in Rheumatology·Jasmine N Stannard, J Michelle Kahlenberg
Sep 20, 2021·Journal of the American Academy of Dermatology·Emily KeyesVictoria P Werth

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